Robert E Rhoads
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Explore the profile of Robert E Rhoads including associated specialties, affiliations and a list of published articles.
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47
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1278
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Recent Articles
1.
Su W, Slevin M, Marzluff W, Rhoads R
Methods Mol Biol
. 2016 May;
1428:93-114.
PMID: 27236794
Since DNA and histone levels must be closely balanced for cell survival, histone expressions are highly regulated. The regulation of replication-dependent histone expression is mainly achieved at the mRNA level,...
2.
Rhoads R
Methods Mol Biol
. 2016 May;
1428:3-27.
PMID: 27236789
Recent advances have made it possible to synthesize mRNA in vitro that is relatively stable when introduced into mammalian cells, has a diminished ability to activate the innate immune response...
3.
Ziemniak M, Mugridge J, Kowalska J, Rhoads R, Gross J, Jemielity J
RNA
. 2016 Jan;
22(4):518-29.
PMID: 26826132
Dcp1/2 is the major eukaryotic RNA decapping complex, comprised of the enzyme Dcp2 and activator Dcp1, which removes the 5' m(7)G cap from mRNA, committing the transcript to degradation. Dcp1/2...
4.
Korneeva N, Song A, Gram H, Edens M, Rhoads R
J Biol Chem
. 2015 Dec;
291(7):3455-67.
PMID: 26668315
The MAPK-interacting kinases 1 and 2 (MNK1 and MNK2) are activated by extracellular signal-regulated kinases 1 and 2 (ERK1/2) or p38 in response to cellular stress and extracellular stimuli that...
5.
Kowalska J, Wypijewska Del Nogal A, Darzynkiewicz Z, Buck J, Nicola C, Kuhn A, et al.
Nucleic Acids Res
. 2014 Aug;
42(16):10245-64.
PMID: 25150148
Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions. We report the synthesis and properties of 11 dinucleotide cap analogs...
6.
Slevin M, Meaux S, Welch J, Bigler R, Miliani de Marval P, Su W, et al.
Mol Cell
. 2014 Mar;
53(6):1020-30.
PMID: 24656133
Histone mRNAs are rapidly degraded when DNA replication is inhibited during S phase with degradation initiating with oligouridylation of the stem loop at the 3' end. We developed a customized...
7.
Grudzien-Nogalska E, Reed B, Rhoads R
J Cell Sci
. 2014 Mar;
127(Pt 10):2326-38.
PMID: 24634508
Downregulation of CPEB1, a sequence-specific RNA-binding protein, in a mouse mammary epithelial cell line (CID-9) causes epithelial-to-mesenchymal transition (EMT), based on several criteria. First, CPEB1 knockdown decreases protein levels of...
8.
Ziemniak M, Szabelski M, Lukaszewicz M, Nowicka A, Darzynkiewicz E, Rhoads R, et al.
RSC Adv
. 2013 Nov;
3(43).
PMID: 24273643
We describe the synthesis and properties of five dinucleotide fluorescent cap analogues labelled at the ribose of the 7-methylguanosine moiety with either anthraniloyl (Ant) or N-methylanthraniloyl (Mant), which have been...
9.
Grudzien-Nogalska E, Kowalska J, Su W, Kuhn A, Slepenkov S, Darzynkiewicz E, et al.
Methods Mol Biol
. 2013 Jan;
969:55-72.
PMID: 23296927
The translational efficiency and stability of synthetic mRNA in both cultured cells and whole animals can be improved by incorporation of modified cap structures at the 5'-end. mRNAs are synthesized...
10.
Su W, Slepenkov S, Slevin M, Lyons S, Ziemniak M, Kowalska J, et al.
RNA
. 2012 Nov;
19(1):1-16.
PMID: 23188809
Metazoan replication-dependent histone mRNAs are only present in S-phase, due partly to changes in their stability. These mRNAs end in a unique stem-loop (SL) that is required for both translation...