Janusz Stepinski
Overview
Explore the profile of Janusz Stepinski including associated specialties, affiliations and a list of published articles.
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62
Citations
1287
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Recent Articles
1.
Lukaszewicz M, Ferenc-Mrozek A, Kokosza J, Stefaniuk A, Stepinski J, Bojarska E, et al.
Eur Biophys J
. 2023 Aug;
52(6-7):487-495.
PMID: 37644211
The Nudt15 enzyme of the NUDIX protein family is the subject of extensive study due to its action on thiopurine drugs used in the treatment of cancer and inflammatory diseases....
2.
Lukaszewicz M, Ferenc-Mrozek A, Bojarska E, Stelmach J, Stepinski J, Darzynkiewicz E
Biochim Biophys Acta Gen Subj
. 2023 Jun;
1867(9):130400.
PMID: 37301333
Recent findings have substantially broadened our knowledge about the diversity of modifications of the 5'end of RNAs, an issue generally attributed to mRNA cap structure (mGpppN). Nudt12 is one of...
3.
Chrabaszczewska M, Winiewska-Szajewska M, Ostrowska N, Bojarska E, Stepinski J, Mancewicz L, et al.
Int J Mol Sci
. 2021 Oct;
22(20).
PMID: 34681586
Nudt16 is a member of the NUDIX family of hydrolases that show specificity towards substrates consisting of a nucleoside diphosphate linked to another moiety X. Several substrates for hNudt16 and...
4.
Ferenc-Mrozek A, Bojarska E, Stepinski J, Darzynkiewicz E, Lukaszewicz M
ACS Omega
. 2020 May;
5(19):10759-10766.
PMID: 32455195
Decapping scavenger enzymes (DcpSs) are important players in mRNA degradation machinery and conserved in eukaryotes. Importantly, human DcpS is the recognized target for spinal muscular atrophy (SMA) and acute myeloid...
5.
Grzela R, Nasilowska K, Lukaszewicz M, Tyras M, Stepinski J, Jankowska-Anyszka M, et al.
RNA
. 2018 Feb;
24(5):633-642.
PMID: 29483298
Human Nudt16 (hNudt16) is a member of the Nudix family of hydrolases, comprising enzymes catabolizing various substrates including canonical (d)NTPs, oxidized (d)NTPs, nonnucleoside polyphosphates, and capped mRNAs. Decapping activity of...
6.
Niedzwiecka A, Nilsson P, Worch R, Stepinski J, Darzynkiewicz E, Virtanen A
Biochim Biophys Acta
. 2016 Jan;
1864(4):331-45.
PMID: 26772900
The mRNA 5' cap structure plays a pivotal role in coordination of eukaryotic translation and mRNA degradation. Poly(A)-specific ribonuclease (PARN) is a dimeric exoribonuclease that efficiently degrades mRNA 3' poly(A)...
7.
Piecyk K, Darzynkiewicz Z, Jankowska-Anyszka M, Ferenc-Mrozek A, Stepinski J, Darzynkiewicz E, et al.
Biochem Biophys Res Commun
. 2015 Jun;
464(1):89-93.
PMID: 26049109
Scavenger decapping enzymes (DcpS) are involved in eukaryotic mRNA degradation process. They catalyze the cleavage of residual cap structure m(7)GpppN and/or short capped oligonucleotides resulting from exosom-mediated the 3' to...
8.
Freire E, Vashisht A, Malvezzi A, Zuberek J, Langousis G, Saada E, et al.
RNA
. 2014 Jun;
20(8):1272-86.
PMID: 24962368
Members of the eIF4E mRNA cap-binding family are involved in translation and the modulation of transcript availability in other systems as part of a three-component complex including eIF4G and eIF4A....
9.
Malecka B, Zabek A, Cias A, Stepinski J, Kutarski A, Ronda J, et al.
Kardiol Pol
. 2014 May;
72(10):960-8.
PMID: 24846370
Background: The passage of a lead in tissues and in the cardiovascular system depends on the implantation technique. The structure of the leads, which is a combination of two or...
10.
Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation
Smietanski M, Werner M, Purta E, Kaminska K, Stepinski J, Darzynkiewicz E, et al.
Nat Commun
. 2014 Jan;
5:3004.
PMID: 24402442
The 5' cap of human messenger RNA contains 2'-O-methylation of the first and often second transcribed nucleotide that is important for its processing, translation and stability. Human enzymes that methylate...