Joanna Zuberek
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Explore the profile of Joanna Zuberek including associated specialties, affiliations and a list of published articles.
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52
Citations
899
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Recent Articles
1.
Warminski M, Depaix A, Ziemkiewicz K, Spiewla T, Zuberek J, Drazkowska K, et al.
Nucleic Acids Res
. 2024 Sep;
52(18):10788-10809.
PMID: 39248095
The recent COVID-19 pandemics have demonstrated the great therapeutic potential of in vitro transcribed (IVT) mRNAs, but improvements in their biochemical properties, such as cellular stability, reactogenicity and translational activity,...
2.
Warminski M, Grab K, Szczepanski K, Spiewla T, Zuberek J, Kowalska J, et al.
Adv Sci (Weinh)
. 2024 Jul;
11(36):e2400994.
PMID: 39049186
Chemical modification of messenger RNA (mRNA) has paved the way for advancing mRNA-based therapeutics. The intricate process of mRNA translation in eukaryotes is orchestrated by numerous proteins involved in complex...
3.
Warminski M, Trepkowska E, Smietanski M, Sikorski P, Baranowski M, Bednarczyk M, et al.
J Am Chem Soc
. 2024 Mar;
146(12):8149-8163.
PMID: 38442005
Eukaryotic mRNAs undergo cotranscriptional 5'-end modification with a 7-methylguanosine cap. In higher eukaryotes, the cap carries additional methylations, such as A─a common epitranscriptomic mark unique to the mRNA 5'-end. This...
4.
Zuberek J, Warzecha M, Dobrowolski M, Modrak-Wojcik A
Eur Biophys J
. 2023 Oct;
52(6-7):497-510.
PMID: 37798395
The cap at the 5'terminus of mRNA is a key determinant of gene expression in eukaryotic cells, which among others is required for cap dependent translation and protects mRNA from...
5.
Wojcik R, Baranowski M, Markiewicz L, Kubacka D, Bednarczyk M, Baran N, et al.
Pharmaceutics
. 2021 Nov;
13(11).
PMID: 34834356
Dinucleotide analogs of the messenger RNA cap (mGpppN) are useful research tools and have potential applications as translational inhibitors or reagents for modification of in vitro transcribed mRNAs. It has...
6.
Rydzik A, Warminski M, Sikorski P, Baranowski M, Walczak S, Kowalska J, et al.
Nucleic Acids Res
. 2017 Jul;
45(15):8661-8675.
PMID: 28666355
Analogues of the mRNA 5'-cap are useful tools for studying mRNA translation and degradation, with emerging potential applications in novel therapeutic interventions including gene therapy. We report the synthesis of...
7.
Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA
Warminski M, Sikorski P, Warminska Z, Lukaszewicz M, Kropiwnicka A, Zuberek J, et al.
Bioconjug Chem
. 2017 Jun;
28(7):1978-1992.
PMID: 28613834
mRNA is a template for protein biosynthesis, and consequently mRNA transport, translation, and turnover are key elements in the overall regulation of gene expression. Along with growing interest in the...
8.
Strenkowska M, Grzela R, Majewski M, Wnek K, Kowalska J, Lukaszewicz M, et al.
Nucleic Acids Res
. 2016 Dec;
44(20):9578-9590.
PMID: 27903882
Along with a growing interest in mRNA-based gene therapies, efforts are increasingly focused on reaching the full translational potential of mRNA, as a major obstacle for in vivo applications is...
9.
Zuberek J, Kuchta K, Hernandez G, Sonenberg N, Ginalski K
Biochim Biophys Acta
. 2016 Jul;
1864(10):1292-303.
PMID: 27374989
The majority of eukaryotic mRNAs are translated in a cap-dependent manner, which requires recognition of the mRNA 5' cap by eIF4E protein. Multiple eIF4E family members have been identified in...
10.
Ziemniak M, Kowalska J, Lukaszewicz M, Zuberek J, Wnek K, Darzynkiewicz E, et al.
Bioorg Med Chem
. 2015 Aug;
23(17):5369-81.
PMID: 26264844
The synthesis and biochemical properties of 17 new mRNA cap analogues are reported. Six of these nucleotides are m(7)GTP derivatives, whereas 11 are 'two headed' tetraphosphate dinucleotides based on a...