Edward Darzynkiewicz
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Explore the profile of Edward Darzynkiewicz including associated specialties, affiliations and a list of published articles.
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120
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2387
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Recent Articles
1.
Geng J, Chrabaszczewska M, Kurpiejewski K, Stankiewicz-Drogon A, Jankowska-Anyszka M, Darzynkiewicz E, et al.
RNA
. 2024 Jul;
30(10):1292-1305.
PMID: 39009378
All cells in our body are equipped with receptors to recognize pathogens and trigger a rapid defense response. As a result, foreign molecules are blocked, and cells are alerted to...
2.
The potential of N2-modified cap analogues for precise genetic manipulation through mRNA engineering
Kurpiejewski K, Stankiewicz-Drogon A, Piecyk K, Rajkowska E, Skrzypczyk P, Geng J, et al.
Front Mol Biosci
. 2024 Feb;
10:1269028.
PMID: 38380271
The technology of mRNA-based drugs is currently being intensively developed and implemented. Medical products of this type are already being used as viral vaccines and could potentially find application in...
3.
Nagaraj S, Stankiewicz-Drogon A, Darzynkiewicz E, Wojda U, Grzela R
Sci Rep
. 2024 Feb;
14(1):4237.
PMID: 38378793
Eukaryotic initiation factor 4E (eIF4E) is a pivotal protein involved in the regulatory mechanism for global protein synthesis in both physiological and pathological conditions. MicroRNAs (miRNAs) play a significant role...
4.
Lukaszewicz M, Ferenc-Mrozek A, Kokosza J, Stefaniuk A, Stepinski J, Bojarska E, et al.
Eur Biophys J
. 2023 Aug;
52(6-7):487-495.
PMID: 37644211
The Nudt15 enzyme of the NUDIX protein family is the subject of extensive study due to its action on thiopurine drugs used in the treatment of cancer and inflammatory diseases....
5.
Andrzejewska A, Grzela R, Stankiewicz-Drogon A, Rogujski P, Nagaraj S, Darzynkiewicz E, et al.
Mol Ther Nucleic Acids
. 2023 Aug;
33:454-468.
PMID: 37588684
We previously have shown that mRNA-based engineering may enhance mesenchymal stem cell (MSC) trafficking. However, optimal conditions for mRNA engineering of MSCs are unknown. Here, we investigated several independent variables:...
6.
Lukaszewicz M, Ferenc-Mrozek A, Bojarska E, Stelmach J, Stepinski J, Darzynkiewicz E
Biochim Biophys Acta Gen Subj
. 2023 Jun;
1867(9):130400.
PMID: 37301333
Recent findings have substantially broadened our knowledge about the diversity of modifications of the 5'end of RNAs, an issue generally attributed to mRNA cap structure (mGpppN). Nudt12 is one of...
7.
Grzela R, Piecyk K, Stankiewicz-Drogon A, Pietrow P, Lukaszewicz M, Kurpiejewski K, et al.
RNA
. 2022 Nov;
29(2):200-216.
PMID: 36418172
mRNA-based vaccines are relatively new technologies that have been in the field of interest of research centers and pharmaceutical companies in recent years. Such therapeutics are an attractive alternative for...
8.
Nagaraj S, Stankiewicz-Drogon A, Darzynkiewicz E, Grzela R
Front Bioeng Biotechnol
. 2022 Nov;
10:1017934.
PMID: 36406230
transcribed (IVT) synthetic mRNAs are in high demand due to their attractive bench to clinic translational processes. Mainly, the procedure to make IVT mRNA using bacteriophage RNA polymerases (RNAP) is...
9.
Chrabaszczewska M, Winiewska-Szajewska M, Ostrowska N, Bojarska E, Stepinski J, Mancewicz L, et al.
Int J Mol Sci
. 2021 Oct;
22(20).
PMID: 34681586
Nudt16 is a member of the NUDIX family of hydrolases that show specificity towards substrates consisting of a nucleoside diphosphate linked to another moiety X. Several substrates for hNudt16 and...
10.
Galloway A, Kaskar A, Ditsova D, Atrih A, Yoshikawa H, Gomez-Moreira C, et al.
Nucleic Acids Res
. 2021 Jun;
49(12):6722-6738.
PMID: 34125914
The m7G cap is ubiquitous on RNAPII-transcribed RNA and has fundamental roles in eukaryotic gene expression, however its in vivo role in mammals has remained unknown. Here, we identified the...