Ewa Grudzien-Nogalska
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Explore the profile of Ewa Grudzien-Nogalska including associated specialties, affiliations and a list of published articles.
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18
Citations
524
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Recent Articles
1.
Argueta S, Wang Y, Zhao H, Diwanji N, Gorgievski M, Cochran E, et al.
Front Immunol
. 2024 Dec;
15:1501365.
PMID: 39735543
Introduction: The approval of chimeric antigen receptor (CAR) T cell therapies for the treatment of B cell malignancies has fueled the development of numerous cell therapies. However, these cell therapies...
2.
Depaix A, Grudzien-Nogalska E, Fedorczyk B, Kiledjian M, Jemielity J, Kowalska J
Front Mol Biosci
. 2022 Sep;
9:854170.
PMID: 36060251
Many eukaryotic and some bacterial RNAs are modified at the 5' end by the addition of cap structures. In addition to the classic 7-methylguanosine 5' cap in eukaryotic mRNA, several...
3.
Sharma S, Yang J, Grudzien-Nogalska E, Shivas J, Kwan K, Kiledjian M
Nat Commun
. 2022 Feb;
13(1):889.
PMID: 35173156
The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5'-end capped RNAs is now well established. Nevertheless, the biological function of this nucleotide metabolite cap remains elusive. Here, we show that...
4.
Sharma S, Grudzien-Nogalska E, Hamilton K, Jiao X, Yang J, Tong L, et al.
Nucleic Acids Res
. 2020 May;
48(12):6788-6798.
PMID: 32432673
We recently reported the presence of nicotinamide adenine dinucleotide (NAD)-capped RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decapping NAD-capped RNAs (deNADding) in...
5.
Doamekpor S, Grudzien-Nogalska E, Mlynarska-Cieslak A, Kowalska J, Kiledjian M, Tong L
Nucleic Acids Res
. 2020 May;
48(11):6136-6148.
PMID: 32374864
In eukaryotes, the DXO/Rai1 enzymes can eliminate most of the incomplete and non-canonical NAD caps through their decapping, deNADding and pyrophosphohydrolase activities. Here, we report that these enzymes can also...
6.
Grudzien-Nogalska E, Wu Y, Jiao X, Cui H, Mateyak M, Hart R, et al.
Nat Chem Biol
. 2019 May;
15(6):575-582.
PMID: 31101919
We recently demonstrated that mammalian cells harbor nicotinamide adenine dinucleotide (NAD)-capped messenger RNAs that are hydrolyzed by the DXO deNADding enzyme. Here, we report that the Nudix protein Nudt12 is...
7.
Bird J, Basu U, Kuster D, Ramachandran A, Grudzien-Nogalska E, Towheed A, et al.
Elife
. 2018 Dec;
7.
PMID: 30526856
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD and NADH, using NAD and NADH as...
8.
Mlynarska-Cieslak A, Depaix A, Grudzien-Nogalska E, Sikorski P, Warminski M, Kiledjian M, et al.
Org Lett
. 2018 Nov;
20(23):7650-7655.
PMID: 30479128
We report the chemical synthesis of a set of nicotinamide adenine dinucleotide (NAD) cap analogues containing chemical modifications that reduce their susceptibility to NAD-RNA-degrading enzymes. These analogues can be incorporated...
9.
Grudzien-Nogalska E, Bird J, Nickels B, Kiledjian M
RNA
. 2018 Jul;
24(10):1418-1425.
PMID: 30045887
RNA 5' cap structures comprising the metabolic effector nicotinamide adenine dinucleotide (NAD) have been identified in diverse organisms. Here we report a simple, two-step procedure to detect and quantitate NAD-capped...
10.
Grudzien-Nogalska E, Kiledjian M
Wiley Interdiscip Rev RNA
. 2016 Jul;
8(1).
PMID: 27425147
Removal of the 5' end cap is a critical determinant controlling mRNA stability and efficient gene expression. Removal of the cap is exquisitely controlled by multiple direct and indirect regulators...