Jacek Jemielity
Overview
Explore the profile of Jacek Jemielity including associated specialties, affiliations and a list of published articles.
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Articles
133
Citations
1853
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0
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Recent Articles
1.
Bernhard H, Petrzilkova H, Popelarova B, Ziemkiewicz K, Bartosik K, Warminski M, et al.
Nat Commun
. 2025 Jan;
16(1):685.
PMID: 39814716
Kinetoplastids are a clade of eukaryotic protozoans that include human parasitic pathogens like trypanosomes and Leishmania species. In these organisms, protein-coding genes are transcribed as polycistronic pre-mRNAs, which need to...
2.
Spiewla T, Grab K, Depaix A, Ziemkiewicz K, Warminski M, Jemielity J, et al.
RNA
. 2024 Dec;
31(2):181-192.
PMID: 39643445
IFITs (interferon-induced proteins with tetratricopeptide repeats) are components of the innate immune response that bind to viral and cellular RNA targets to inhibit translation and replication. The RNA target recognition...
3.
Grab K, Fido M, Spiewla T, Warminski M, Jemielity J, Kowalska J
Nucleic Acids Res
. 2024 Oct;
52(21):e100.
PMID: 39445825
Recent years have led to the identification of a number of enzymes responsible for RNA decapping. This has provided a basis for further research to identify their role, dependency and...
4.
Warminski M, Depaix A, Ziemkiewicz K, Spiewla T, Zuberek J, Drazkowska K, et al.
Nucleic Acids Res
. 2024 Sep;
52(18):10788-10809.
PMID: 39248095
The recent COVID-19 pandemics have demonstrated the great therapeutic potential of in vitro transcribed (IVT) mRNAs, but improvements in their biochemical properties, such as cellular stability, reactogenicity and translational activity,...
5.
Surynt P, Wojtczak B, Chrominski M, Panecka-Hofman J, Kwapiszewska K, Kalwarczyk T, et al.
Org Biomol Chem
. 2024 Aug;
22(33):6763-6790.
PMID: 39105613
The trimethylguanosine (TMG) cap is a motif present at the 5' end of small nuclear RNAs, which are involved in RNA splicing. The TMG cap plays a crucial role in...
6.
Warminski M, Grab K, Szczepanski K, Spiewla T, Zuberek J, Kowalska J, et al.
Adv Sci (Weinh)
. 2024 Jul;
11(36):e2400994.
PMID: 39049186
Chemical modification of messenger RNA (mRNA) has paved the way for advancing mRNA-based therapeutics. The intricate process of mRNA translation in eukaryotes is orchestrated by numerous proteins involved in complex...
7.
Warminski M, Trepkowska E, Smietanski M, Sikorski P, Baranowski M, Bednarczyk M, et al.
J Am Chem Soc
. 2024 Mar;
146(12):8149-8163.
PMID: 38442005
Eukaryotic mRNAs undergo cotranscriptional 5'-end modification with a 7-methylguanosine cap. In higher eukaryotes, the cap carries additional methylations, such as A─a common epitranscriptomic mark unique to the mRNA 5'-end. This...
8.
Zhang H, Ociepa M, Nassir M, Zheng B, Lewicki S, Salmaso V, et al.
Nat Chem
. 2023 Oct;
16(2):249-258.
PMID: 37857844
Nucleoside diphosphates and triphosphates impact nearly every aspect of biochemistry; however, the use of such compounds as tools or medicinal leads for nucleotide-dependent enzymes and receptors is hampered by their...
9.
Warminski M, Mamot A, Depaix A, Kowalska J, Jemielity J
Acc Chem Res
. 2023 Oct;
56(20):2814-2826.
PMID: 37782471
Messenger ribonucleic acid (mRNA) is the universal cellular instruction for ribosomes to produce proteins. Proteins are responsible for most of the functions of living organisms, and their abnormal structure or...
10.
Zmudzinski M, Rut W, Olech K, Granda J, Giurg M, Burda-Grabowska M, et al.
Sci Rep
. 2023 Jun;
13(1):9161.
PMID: 37280236
Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (M, 3CL) and papain-like protease (PL) are responsible for viral polyprotein cleavage-a process crucial...