Nicole M Martinez
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Explore the profile of Nicole M Martinez including associated specialties, affiliations and a list of published articles.
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16
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1220
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Recent Articles
1.
Rodell R, Robalin N, Martinez N
Trends Biochem Sci
. 2023 Dec;
49(1):12-27.
PMID: 38097411
The uridine modifications pseudouridine (Ψ), dihydrouridine, and 5-methyluridine are present in eukaryotic mRNAs. Many uridine-modifying enzymes are associated with human disease, underscoring the importance of uncovering the functions of uridine...
2.
Montes M, Martinez N
Mol Cell
. 2023 Feb;
83(4):503-506.
PMID: 36804913
Adachi et al. and Song et al. demonstrate the feasibility of engineering pseudouridylation at specific sites and its utility to correct disease-causing premature termination codons (PTCs) in human cells.
3.
Martinez N, Su A, Burns M, Nussbacher J, Schaening C, Sathe S, et al.
Mol Cell
. 2022 Jan;
82(3):645-659.e9.
PMID: 35051350
Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is dynamically regulated. Here, we investigate when in their life cycle mRNAs become pseudouridylated to illuminate the potential...
4.
Martinez N, Schaening-Burgos C, Gilbert W
Methods Enzymol
. 2021 Sep;
658:277-310.
PMID: 34517951
Pseudouridine (Ψ) is one of the most abundant modifications in cellular RNAs. High-throughput pseudouridine profiling of eukaryotic mRNAs from cells has revealed novel sites of modification across the transcriptome. Pseudouridine...
5.
Martinez N, Gilbert W
Methods Mol Biol
. 2021 Jun;
2298:379-397.
PMID: 34085256
Pseudouridine profiling has revealed many previously unknown sites of the RNA modification pseudouridine (Ψ) in cellular RNAs. All organisms express multiple pseudouridine synthases (PUS) whose RNA targets and mechanisms of...
6.
Borchardt E, Martinez N, Gilbert W
Annu Rev Genet
. 2020 Sep;
54:309-336.
PMID: 32870730
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of noncoding RNA in human cells. The known molecular functions of pseudouridine, which...
7.
Carlile T, Martinez N, Schaening C, Su A, Bell T, Zinshteyn B, et al.
Nat Chem Biol
. 2019 Sep;
15(10):966-974.
PMID: 31477916
Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions that affect gene expression. Messenger RNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but...
8.
Martinez N, Gilbert W
Quant Biol
. 2018 Dec;
6(3):210-227.
PMID: 30533247
Background: Cellular non-coding RNAs are extensively modified post-transcriptionally, with more than 100 chemically distinct nucleotides identified to date. In the past five years, new sequencing based methods have revealed widespread...
9.
Ajith S, Gazzara M, Cole B, Shankarling G, Martinez N, Mallory M, et al.
RNA Biol
. 2016 Apr;
13(6):569-81.
PMID: 27096301
CELF2 is an RNA binding protein that has been implicated in developmental and signal-dependent splicing in the heart, brain and T cells. In the heart, CELF2 expression decreases during development,...
10.
Boskovic Z, Kemp M, Freedy A, Viswanathan V, Pop M, Fuller J, et al.
ACS Chem Biol
. 2016 Apr;
11(7):1844-51.
PMID: 27064299
Unbiased binding assays involving small-molecule microarrays were used to identify compounds that display unique patterns of selectivity among members of the zinc-dependent histone deacetylase family of enzymes. A novel, hydroxyquinoline-containing...