Rewriting the Message: Harnessing RNA Pseudouridylation to Tackle Disease

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2023 Feb 22

PMID 36804913

Authors

Matias Montes

Nicole M Martinez

Affiliations

Soon will be listed here.

Abstract

Adachi et al. and Song et al. demonstrate the feasibility of engineering pseudouridylation at specific sites and its utility to correct disease-causing premature termination codons (PTCs) in human cells.

Citing Articles

Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons.

Luo N, Huang Q, Dong L, Liu W, Song J, Sun H Nat Biotechnol. 2024; 43(1):114-123.

PMID: 38448662 DOI: 10.1038/s41587-024-02165-8.