Bioorganic & Medicinal Chemistry Letters
Overview
Bioorganic & Medicinal Chemistry Letters is a peer-reviewed scientific journal that publishes concise and timely research articles in the field of bioorganic and medicinal chemistry. It focuses on the discovery and development of novel bioactive compounds, their structure-activity relationships, and their potential applications in drug design and therapy. The journal provides a platform for researchers to share their innovative findings and advancements in the field, contributing to the progress of medicinal chemistry and drug discovery.
Details
Details
Abbr.
Bioorg Med Chem Lett
Start
1991
End
Continuing
Frequency
Semimonthly, 1994-
p-ISSN
0960-894X
e-ISSN
1464-3405
Country
United Kingdom
Language
English
Specialty
Biochemistry
Metrics
Metrics
h-index / Ranks: 1149
166
SJR / Ranks: 8789
508
CiteScore / Ranks: 4374
5.50
JIF / Ranks: 3958
2.7
Recent Articles
1.
Dorich S, Auger A, Wang L, Burch J, Pellerin C, Chan S, et al.
Bioorg Med Chem Lett
. 2025 Mar;
:130184.
PMID: 40089037
NLRP3 is a key regulator of the innate immune system involved in sensing a variety of pathogen and danger signals. Priming and activation of NLRP3 leads to the release and...
2.
Design, synthesis, and biological evaluation of novel aminopyrimidine derivatives as EGFR inhibitors
Wang H, Gui Y, Cui S, Long X, Fan W, Tang C
Bioorg Med Chem Lett
. 2025 Mar;
:130188.
PMID: 40089036
The treatment of non-small cell lung cancer (NSCLC) is significantly challenged by the development of acquired resistance to third-generation epidermal growth factor receptor (EGFR) inhibitors, such as Osimertinib, which limits...
3.
Zhang N, Zhu J, Hu X, Zhou Y, Wang Q, Cai S, et al.
Bioorg Med Chem Lett
. 2025 Mar;
:130187.
PMID: 40086606
Accurate identification of programmed cell death ligand 1 (PD-L1) expression is crucial for anti-tumor immunotherapy. However, the heterogeneity of PD-L1 expression in tumors makes it challenging to detect by immunohistochemistry....
4.
Yuan L, Chu Q, Li F, Zhang D, Yu Y, Liu J
Bioorg Med Chem Lett
. 2025 Mar;
:130185.
PMID: 40086605
According to the bioisosterism principle and activity substructure splicing strategy, new pamicogrel derivatives were designed, synthesized, and evaluated for their antiplatelet aggregation activities in vitro. Bioassay results showed that compound...
5.
Hozain D, Cottet K, Fromentin Y, Dugay A, Souquet F, Mouray E, et al.
Bioorg Med Chem Lett
. 2025 Mar;
:130186.
PMID: 40086604
This study introduces third-generation derivatives of guttiferone A, designed to enhance both bioactivity and selectivity against Plasmodium falciparum and Trypanosoma brucei. Following an optimized synthetic route, two dioxolane derivatives of...
6.
He J, Illingworth H, Ullrich S, Ghosh P, Ton J, Jackson C, et al.
Bioorg Med Chem Lett
. 2025 Mar;
:130176.
PMID: 40081602
Alphaviruses like the Chikungunya virus cause severe outbreaks; however, no specific treatments are available. Their viral replication depends on the nsP2 cysteine protease, a promising but underexplored target for drug...
7.
Hu S, Zhong Q, Xie X, Zhang S, Wang J, Liu H, et al.
Bioorg Med Chem Lett
. 2025 Mar;
:130168.
PMID: 40074013
Viral infectious diseases have been seriously affecting human life and health. SARS-CoV-2 was the pathogen that caused Coronavirus Disease 2019 (COVID-19), and the impact of COVID-19 is still existing. Enterovirus...
8.
Reddyrajula R, Priya Varshini K, Shankaraiah N
Bioorg Med Chem Lett
. 2025 Mar;
:130167.
PMID: 40074012
Microtubules, as dynamic regulators in many cellular processes, remain pivotal targets in cancer chemotherapy. Among the structural motifs explored, the benzimidazole scaffold has emerged as a privileged heterocyclic ring system...
9.
Liu W, Du J, Qin Z, Zhao M, Du S, Xie J, et al.
Bioorg Med Chem Lett
. 2025 Mar;
121:130159.
PMID: 40068740
Candida albicans (C. albicans) is the most common cause of invasive Candida infections worldwide. The acquired resistance of C. albicans to fluconazole, a first-line antifungal drug, has been frequently reported,...
10.
Tsalyy A, Kral M, Reiberger R, Majer P, Konvalinka J, Kozisek M, et al.
Bioorg Med Chem Lett
. 2025 Mar;
121:130178.
PMID: 40064244
The polymerase acidic (PA) subunit of the influenza virus, an endonuclease of the RNA-dependent RNA polymerase, represents a viable target for anti-influenza therapies, as evidenced by the efficacy of the...