Michael J Mallory
Overview
Explore the profile of Michael J Mallory including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
831
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Recent Articles
1.
Agosto L, Mallory M, Ferretti M, Blake D, Krick K, Gazzara M, et al.
Cell Rep
. 2023 Mar;
42(3):112273.
PMID: 36933216
Chromatin regulation and alternative splicing are both critical mechanisms guiding gene expression. Studies have demonstrated that histone modifications can influence alternative splicing decisions, but less is known about how alternative...
2.
Rivera O, Mallory M, Quesnel-Vallieres M, Chatrikhi R, Schultz D, Carroll M, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(15).
PMID: 33876749
Most genes associated with acute myeloid leukemia (AML) are mutated in less than 10% of patients, suggesting that alternative mechanisms of gene disruption contribute to this disease. Here, we find...
3.
Thompson M, Dittmar M, Mallory M, Bhat P, Ferretti M, Fontoura B, et al.
Elife
. 2020 Dec;
9.
PMID: 33269701
Viral infection induces the expression of numerous host genes that impact the outcome of infection. Here, we show that infection of human lung epithelial cells with influenza A virus (IAV)...
4.
Mallory M, McClory S, Chatrikhi R, Gazzara M, Ontiveros R, Lynch K
Nucleic Acids Res
. 2020 Apr;
48(10):5710-5719.
PMID: 32338744
RNA binding proteins (RBPs) frequently regulate the expression of other RBPs in mammalian cells. Such cross-regulation has been proposed to be important to control networks of coordinated gene expression; however,...
5.
Chatrikhi R, Mallory M, Gazzara M, Agosto L, Zhu W, Litterman A, et al.
Cell Rep
. 2019 Sep;
28(11):2795-2806.e3.
PMID: 31509743
The 3' UTR (UTR) of human mRNAs plays a critical role in controlling protein expression and function. Importantly, 3' UTRs of human messages are not invariant for each gene but...
6.
Thompson M, Munoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara M, et al.
Nat Commun
. 2018 Jun;
9(1):2407.
PMID: 29921878
Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and NS1-BP...
7.
Shinde M, Sidoli S, Kulej K, Mallory M, Radens C, Reicherter A, et al.
J Biol Chem
. 2017 Sep;
292(44):18240-18255.
PMID: 28916722
Glycogen synthase kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed protein kinase that regulates multiple signaling pathways. kinase assays and genetic and pharmacological manipulations of GSK-3 have identified more than...
8.
Gazzara M, Mallory M, Roytenberg R, Lindberg J, Jha A, Lynch K, et al.
Genome Res
. 2017 May;
27(8):1360-1370.
PMID: 28512194
Over 95% of human multi-exon genes undergo alternative splicing, a process important in normal development and often dysregulated in disease. We sought to analyze the global splicing regulatory network of...
9.
Ajith S, Gazzara M, Cole B, Shankarling G, Martinez N, Mallory M, et al.
RNA Biol
. 2016 Apr;
13(6):569-81.
PMID: 27096301
CELF2 is an RNA binding protein that has been implicated in developmental and signal-dependent splicing in the heart, brain and T cells. In the heart, CELF2 expression decreases during development,...
10.
Martinez N, Agosto L, Qiu J, Mallory M, Gazzara M, Barash Y, et al.
Genes Dev
. 2015 Oct;
29(19):2054-66.
PMID: 26443849
Alternative splicing is prevalent among genes encoding signaling molecules; however, the functional consequence of differential isoform expression remains largely unknown. Here we demonstrate that, in response to T-cell activation, the...