Stuart L Schreiber
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Explore the profile of Stuart L Schreiber including associated specialties, affiliations and a list of published articles.
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347
Citations
29593
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Recent Articles
1.
Humeidi R, Oshiro-Rapley N, Gu X, An J, Ananthakrishnan A, Creasey E, et al.
J Am Chem Soc
. 2025 Mar;
PMID: 40067145
Colonic mucus forms a first line of defense against bacterial invasion while providing nutrition to support coinhabiting microbes in the gut. Mucus is composed of polymeric networks of mucin proteins,...
2.
Tan Z, Adade J, Gu X, Hecht C, Salcius M, Tong B, et al.
Cell Chem Biol
. 2025 Jan;
PMID: 39753134
Chemical inducers of proximity (CIPs) are molecules that recruit one protein to another and introduce new functionalities toward modulating protein states and activities. While CIP-mediated recruitment of E3 ligases is...
3.
Gill S, Mandigo T, Elmali A, Leger B, Yang B, Tran S, et al.
medRxiv
. 2024 Dec;
PMID: 39711723
Congenital disorders of glycosylation (CDG) comprise a class of inborn errors of metabolism resulting from pathogenic variants in genes coding for enzymes involved in the asparagine-linked glycosylation of proteins. Unexpectedly...
4.
Luth M, Godinez-Macias K, Chen D, Okombo J, Thathy V, Cheng X, et al.
Science
. 2024 Nov;
386(6725):eadk9893.
PMID: 39607932
Surveillance of drug resistance and the discovery of novel targets-key objectives in the fight against malaria-rely on identifying resistance-conferring mutations in parasites. Current approaches, while successful, require laborious experimentation or...
5.
Ogasawara D, Konrad D, Tan Z, Carey K, Luo J, Won S, et al.
Cell Chem Biol
. 2024 Nov;
31(12):2138-2155.e32.
PMID: 39547236
Chemical proteomics enables the global analysis of small molecule-protein interactions in native biological systems and has emerged as a versatile approach for ligand discovery. The range of small molecules explored...
6.
Njomen E, Hayward R, DeMeester K, Ogasawara D, Dix M, Nguyen T, et al.
Nat Chem
. 2024 Aug;
16(10):1592-1604.
PMID: 39138346
Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with...
7.
Schreiber S
Cell Chem Biol
. 2024 Jun;
31(6):1050-1063.
PMID: 38861986
This Perspective explores molecular glues and bifunctional compounds-proximity-inducing compounds-and offers a framework to understand and exploit their similarity to hotspots, missense mutations, and posttranslational modifications (PTMs). This view is also...
8.
Ence C, Uddin T, Borrel J, Mittal P, Xie H, Zoller J, et al.
ACS Infect Dis
. 2024 May;
10(6):2212-2221.
PMID: 38743643
Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth inhibition in vitro and in vivo, including in...
9.
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders
Liu Z, Remsberg J, Li H, Njomen E, DeMeester K, Tao Y, et al.
J Am Chem Soc
. 2024 Apr;
146(15):10393-10406.
PMID: 38569115
Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile way to discover ligands for proteins in native biological systems. Here, we describe a set of stereo- and regiochemically...
10.
Ence C, Uddin T, Borrel J, Mittal P, Xie H, Zoller J, et al.
bioRxiv
. 2024 Mar;
PMID: 38464220
Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth inhibition and , including in models of infection....