Nicholas D P Cosford
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Explore the profile of Nicholas D P Cosford including associated specialties, affiliations and a list of published articles.
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86
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2086
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Recent Articles
1.
Wu J, Baranowski M, Aleshin A, Isiorho E, Lambert L, De Backer L, et al.
ACS Omega
. 2025 Feb;
10(5):4912-4926.
PMID: 39959108
The human H1-related phosphatase (VHR; ) is a critical positive regulator of the innate immune response. Recent studies suggest that inhibiting VHR could be beneficial in treating sepsis and septic...
2.
Han Y, Lambert L, De Backer L, Wu J, Cosford N, Tautz L
Methods Mol Biol
. 2023 Aug;
2706:167-175.
PMID: 37558948
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific enzyme that regulates the signaling molecules that control synaptic plasticity and neuronal function. Dysregulation of STEP is linked to the pathophysiology of...
3.
Bhattacharya S, Piya S, Ma H, Sharma P, Zhang Q, Baran N, et al.
Mol Cancer Res
. 2023 Feb;
21(6):548-563.
PMID: 36787422
Implications: ULK1 drives a cell-intrinsic adaptive resistance in AML and targeting ULK1-mediated autophagy can synergize with existing and emerging AML therapies to overcome drug-resistance and induce apoptosis.
4.
Baranowski M, Wu J, Han Y, Lambert L, Cosford N, Tautz L
Bio Protoc
. 2022 Oct;
12(18).
PMID: 36248604
Disturbance of the dynamic balance between protein tyrosine phosphorylation and dephosphorylation, modulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), is known to be crucial for the development...
5.
Haass-Koffler C, Francis T, Gandhi P, Patel R, Naemuddin M, Nielsen C, et al.
SLAS Discov
. 2022 Oct;
27(8):448-459.
PMID: 36210051
Background: Stress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRF and CRF), and the CRF-binding protein (CRFBP). Whereas decades of research has focused on...
6.
Yue P, Zhu Y, Brotherton-Pleiss C, Fu W, Verma N, Chen J, et al.
Cancer Lett
. 2022 Mar;
534:215613.
PMID: 35276290
Signal transducer and activator of transcription (Stat)3 is a valid anticancer therapeutic target. We have discovered a highly potent chemotype that amplifies the Stat3-inhibitory activity of lead compounds to levels...
7.
Bata N, Cosford N
ACS Pharmacol Transl Sci
. 2021 Dec;
4(6):1728-1746.
PMID: 34927007
Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular turnover. While these two pathways are distinct, they can also regulate each other, and central components of the apoptosis...
8.
Raveendra-Panickar D, Finlay D, Izidro Layng F, Lambert L, Celeridad M, Zhao M, et al.
J Biol Chem
. 2021 Dec;
298(1):101477.
PMID: 34896393
Disturbance of the dynamic balance between tyrosine phosphorylation and dephosphorylation of signaling molecules, controlled by protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is known to lead to the development...
9.
Bata N, Chaikuad A, Bakas N, Limpert A, Lambert L, Sheffler D, et al.
J Med Chem
. 2021 Nov;
65(2):1352-1369.
PMID: 34807584
Serine/threonine-protein kinases 3 and 4 (STK3 and STK4, respectively) are key components of the Hippo signaling pathway, which regulates cell proliferation and death and provides a potential therapeutic target for...
10.
Bleicher L, Cosford N
J Org Chem
. 2021 Jul;
64(14):5299-5300.
PMID: 34237847
No abstract available.