Mitchell Vamos
Overview
Explore the profile of Mitchell Vamos including associated specialties, affiliations and a list of published articles.
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9
Citations
597
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Recent Articles
1.
Ren H, Bakas N, Vamos M, Chaikuad A, Limpert A, Wimer C, et al.
J Med Chem
. 2020 Nov;
63(23):14609-14625.
PMID: 33200929
Inhibition of autophagy, the major cellular recycling pathway in mammalian cells, is a promising strategy for the treatment of triple-negative breast cancer (TNBC). We previously reported SBI-0206965, a small molecule...
2.
Finlay D, Teriete P, Vamos M, Cosford N, Vuori K
F1000Res
. 2017 May;
6:587.
PMID: 28529715
The heterogeneous group of diseases collectively termed cancer results not just from aberrant cellular proliferation but also from a lack of accompanying homeostatic cell death. Indeed, cancer cells regularly acquire...
3.
Pache L, Dutra M, Spivak A, Marlett J, Murry J, Hwang Y, et al.
Cell Host Microbe
. 2015 Sep;
18(3):345-53.
PMID: 26355217
Combination antiretroviral therapy (ART) is able to suppress HIV-1 replication to undetectable levels. However, the persistence of latent viral reservoirs allows for a rebound of viral load upon cessation of...
4.
Egan D, Chun M, Vamos M, Zou H, Rong J, Miller C, et al.
Mol Cell
. 2015 Jun;
59(2):285-97.
PMID: 26118643
Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine kinase in the core autophagy pathway...
5.
Vamos M, Cosford N
J Org Chem
. 2014 Feb;
79(5):2274-80.
PMID: 24490824
A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot,...
6.
Finlay D, Vamos M, Gonzalez-Lopez M, Ardecky R, Ganji S, Yuan H, et al.
Mol Cancer Ther
. 2013 Nov;
13(1):5-15.
PMID: 24194568
TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it shows apoptosis-inducing activity in transformed, but not in normal, cells. As with most anticancer agents, however, its clinical use...
7.
Vamos M, Welsh K, Finlay D, Lee P, Mace P, Snipas S, et al.
ACS Chem Biol
. 2013 Jan;
8(4):725-32.
PMID: 23323685
A series of novel, potent antagonists of the inhibitor of apoptosis proteins (IAPs) were synthesized in a highly convergent and rapid fashion (≤6 steps) using the Ugi four-component reaction as...
8.
Sheffler D, Wenthur C, Bruner J, Carrington S, Vinson P, Gogi K, et al.
Bioorg Med Chem Lett
. 2012 May;
22(12):3921-5.
PMID: 22607673
Herein we report the discovery and SAR of a novel metabotropic glutamate receptor 3 (mGlu(3)) NAM probe (ML289) with 15-fold selectivity versus mGlu(2). The mGlu(3) NAM was discovered via a...
9.
Vamos M, Kobayashi Y
J Org Chem
. 2008 Apr;
73(10):3938-41.
PMID: 18416575
The efficient, scalable preparation of both enantiomers of 2-(1-hydroxy-2-oxocyclohexyl)acetic acid in enantiomerically pure form is reported using environmentally benign conditions in 30% overall yield (6 steps) for the (S)-isomer, in...