Graham T Dempsey
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Explore the profile of Graham T Dempsey including associated specialties, affiliations and a list of published articles.
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25
Citations
1826
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Recent Articles
1.
Fink J, Delaney-Busch N, Dawes R, Nanou E, Folts C, Harikrishnan K, et al.
Commun Biol
. 2024 Nov;
7(1):1447.
PMID: 39506078
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by hypermethylation of expanded CGG repeats (>200) in the FMR1 gene leading to gene silencing and loss of Fragile X Messenger...
2.
Liu P, Zhang H, Werley C, Pichler M, Ryan S, Lewarch C, et al.
Pain
. 2023 Nov;
165(4):922-940.
PMID: 37963235
Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics....
3.
Borja G, Zhang H, Harwood B, Jacques J, Grooms J, Chantre R, et al.
Front Mol Neurosci
. 2022 Jul;
15:896320.
PMID: 35860501
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types....
4.
Williams L, Gerber D, Elder A, Tseng W, Baru V, Delaney-Busch N, et al.
Mol Ther Nucleic Acids
. 2022 Jul;
29:189-203.
PMID: 35860385
Mutations in the gene are the cause of an ultra-rare neurological disorder characterized by intellectual disability, impaired speech, motor delay, and hypotonia evolving to spasticity, central sleep apnea, and premature...
5.
Simkin D, Ambrosi C, Marshall K, Williams L, Eisenberg J, Gharib M, et al.
Trends Pharmacol Sci
. 2022 Apr;
43(5):392-405.
PMID: 35427475
Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the field of in vitro disease modeling, granting us access to disease-pertinent human cells of the central nervous system....
6.
Simkin D, Papakis V, Bustos B, Ambrosi C, Ryan S, Baru V, et al.
Stem Cell Reports
. 2022 Mar;
17(4):993-1008.
PMID: 35276091
The ability to precisely edit the genome of human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 has enabled the development of cellular models that can address genotype to phenotype...
7.
Zhang Y, Quraishi I, McClure H, Williams L, Cheng Y, Kale S, et al.
FASEB J
. 2021 Nov;
35(12):e22053.
PMID: 34820911
Mutations in KCNC3, the gene that encodes the Kv3.3 voltage dependent potassium channel, cause Spinocerebellar Ataxia type 13 (SCA13), a disease associated with disrupted motor behaviors, progressive cerebellar degeneration, and...
8.
Borja G, Shroff H, Upadhyay H, Liu P, Baru V, Cheng Y, et al.
Methods Mol Biol
. 2020 Sep;
2191:109-134.
PMID: 32865742
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable...
9.
Zhang H, Moyer B, Yu V, McGivern J, Jarosh M, Werley C, et al.
SLAS Discov
. 2020 Apr;
25(5):434-446.
PMID: 32292096
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors...
10.
Pfeiffer-Kaushik E, Smith G, Cai B, Dempsey G, Hortigon-Vinagre M, Zamora V, et al.
J Pharmacol Toxicol Methods
. 2019 Jul;
99:106612.
PMID: 31319140
Introduction: Voltage-sensitive optical (VSO) sensors offer a minimally invasive method to study the time course of repolarization of the cardiac action potential (AP). This Comprehensive in vitro Proarrhythmia Assay (CiPA)...