Hansini Upadhyay
Overview
Explore the profile of Hansini Upadhyay including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
77
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0
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Recent Articles
1.
Fink J, Delaney-Busch N, Dawes R, Nanou E, Folts C, Harikrishnan K, et al.
Commun Biol
. 2024 Nov;
7(1):1447.
PMID: 39506078
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by hypermethylation of expanded CGG repeats (>200) in the FMR1 gene leading to gene silencing and loss of Fragile X Messenger...
2.
Iwamoto N, Liu Y, Frank-Kamenetsky M, Maguire A, Tseng W, Taborn K, et al.
Mol Ther Nucleic Acids
. 2024 Jul;
35(3):102246.
PMID: 39027419
Huntington's disease (HD) is an autosomal dominant disease caused by the expansion of cytosine-adenine-guanine (CAG) repeats in one copy of the gene (mutant HTT, mHTT). The unaffected gene encodes wild-type...
3.
Tian H, Davis H, Wong-Campos J, Park P, Fan L, Gmeiner B, et al.
Nat Methods
. 2023 Feb;
20(3):469.
PMID: 36765248
No abstract available.
4.
Tian H, Davis H, Wong-Campos J, Park P, Fan L, Gmeiner B, et al.
Nat Methods
. 2023 Jan;
20(7):1082-1094.
PMID: 36624211
Video-based screening of pooled libraries is a powerful approach for directed evolution of biosensors because it enables selection along multiple dimensions simultaneously from large libraries. Here we develop a screening...
5.
Williams L, Gerber D, Elder A, Tseng W, Baru V, Delaney-Busch N, et al.
Mol Ther Nucleic Acids
. 2022 Jul;
29:189-203.
PMID: 35860385
Mutations in the gene are the cause of an ultra-rare neurological disorder characterized by intellectual disability, impaired speech, motor delay, and hypotonia evolving to spasticity, central sleep apnea, and premature...
6.
Borja G, Shroff H, Upadhyay H, Liu P, Baru V, Cheng Y, et al.
Methods Mol Biol
. 2020 Sep;
2191:109-134.
PMID: 32865742
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable...
7.
Nguyen C, Upadhyay H, Murphy M, Borja G, Rozsahegyi E, Barnett A, et al.
Biomed Opt Express
. 2019 Feb;
10(2):789-806.
PMID: 30800515
Transmembrane voltage and intracellular calcium concentration are coupled parameters essential to the function of neurons, cardiomyocytes, and other excitable cells. Here we introduce the microscope for simultaneous optogenetic stimulation and...
8.
Werley C, Brookings T, Upadhyay H, Williams L, McManus O, Dempsey G
Curr Protoc Pharmacol
. 2017 Sep;
78:11.20.1-11.20.24.
PMID: 28892145
A key challenge for establishing a phenotypic screen for neuronal excitability is measurement of membrane potential changes with high throughput and accuracy. Most approaches for probing excitability rely on low-throughput,...