Christopher A Werley
Overview
Explore the profile of Christopher A Werley including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
837
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Recent Articles
1.
Liu P, Zhang H, Werley C, Pichler M, Ryan S, Lewarch C, et al.
Pain
. 2023 Nov;
165(4):922-940.
PMID: 37963235
Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics....
2.
Tian H, Davis H, Wong-Campos J, Park P, Fan L, Gmeiner B, et al.
Nat Methods
. 2023 Feb;
20(3):469.
PMID: 36765248
No abstract available.
3.
Tian H, Davis H, Wong-Campos J, Park P, Fan L, Gmeiner B, et al.
Nat Methods
. 2023 Jan;
20(7):1082-1094.
PMID: 36624211
Video-based screening of pooled libraries is a powerful approach for directed evolution of biosensors because it enables selection along multiple dimensions simultaneously from large libraries. Here we develop a screening...
4.
Borja G, Zhang H, Harwood B, Jacques J, Grooms J, Chantre R, et al.
Front Mol Neurosci
. 2022 Jul;
15:896320.
PMID: 35860501
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types....
5.
Borja G, Shroff H, Upadhyay H, Liu P, Baru V, Cheng Y, et al.
Methods Mol Biol
. 2020 Sep;
2191:109-134.
PMID: 32865742
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable...
6.
Werley C, Boccardo S, Rigamonti A, Hansson E, Cohen A
Nat Commun
. 2020 Aug;
11(1):3881.
PMID: 32753572
Cells typically respond to chemical or physical perturbations via complex signaling cascades which can simultaneously affect multiple physiological parameters, such as membrane voltage, calcium, pH, and redox potential. Protein-based fluorescent...
7.
Zhang H, Moyer B, Yu V, McGivern J, Jarosh M, Werley C, et al.
SLAS Discov
. 2020 Apr;
25(5):434-446.
PMID: 32292096
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors...
8.
McManus O, Werley C, Dempsey G
J Gen Physiol
. 2019 Mar;
151(6):714-717.
PMID: 30902836
No abstract available.
9.
Nguyen C, Upadhyay H, Murphy M, Borja G, Rozsahegyi E, Barnett A, et al.
Biomed Opt Express
. 2019 Feb;
10(2):789-806.
PMID: 30800515
Transmembrane voltage and intracellular calcium concentration are coupled parameters essential to the function of neurons, cardiomyocytes, and other excitable cells. Here we introduce the microscope for simultaneous optogenetic stimulation and...
10.
Williams L, Joshi V, Murphy M, Ferrante J, Werley C, Brookings T, et al.
Neurochem Res
. 2019 Jan;
44(3):714-725.
PMID: 30603979
Induced pluripotent stem (iPS) cells offer the exciting opportunity for modeling neurological disorders in vitro in the context of a human genetic background. While significant progress has been made in...