Owen B McManus
Overview
Explore the profile of Owen B McManus including associated specialties, affiliations and a list of published articles.
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45
Citations
850
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Recent Articles
1.
Liu P, Zhang H, Werley C, Pichler M, Ryan S, Lewarch C, et al.
Pain
. 2023 Nov;
165(4):922-940.
PMID: 37963235
Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics....
2.
Borja G, Zhang H, Harwood B, Jacques J, Grooms J, Chantre R, et al.
Front Mol Neurosci
. 2022 Jul;
15:896320.
PMID: 35860501
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types....
3.
Simkin D, Ambrosi C, Marshall K, Williams L, Eisenberg J, Gharib M, et al.
Trends Pharmacol Sci
. 2022 Apr;
43(5):392-405.
PMID: 35427475
Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the field of in vitro disease modeling, granting us access to disease-pertinent human cells of the central nervous system....
4.
Simkin D, Papakis V, Bustos B, Ambrosi C, Ryan S, Baru V, et al.
Stem Cell Reports
. 2022 Mar;
17(4):993-1008.
PMID: 35276091
The ability to precisely edit the genome of human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 has enabled the development of cellular models that can address genotype to phenotype...
5.
Zhang Y, Quraishi I, McClure H, Williams L, Cheng Y, Kale S, et al.
FASEB J
. 2021 Nov;
35(12):e22053.
PMID: 34820911
Mutations in KCNC3, the gene that encodes the Kv3.3 voltage dependent potassium channel, cause Spinocerebellar Ataxia type 13 (SCA13), a disease associated with disrupted motor behaviors, progressive cerebellar degeneration, and...
6.
Borja G, Shroff H, Upadhyay H, Liu P, Baru V, Cheng Y, et al.
Methods Mol Biol
. 2020 Sep;
2191:109-134.
PMID: 32865742
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable...
7.
Zhang H, Moyer B, Yu V, McGivern J, Jarosh M, Werley C, et al.
SLAS Discov
. 2020 Apr;
25(5):434-446.
PMID: 32292096
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors...
8.
Coussens N, Sittampalam G, Jonson S, Hall M, Gorby H, Tamiz A, et al.
J Pharmacol Exp Ther
. 2019 Sep;
371(2):396-408.
PMID: 31481516
Opioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and significant social and economic impact. Curbing this crisis requires collaboration among academic, government, and industrial partners...
9.
McManus O, Werley C, Dempsey G
J Gen Physiol
. 2019 Mar;
151(6):714-717.
PMID: 30902836
No abstract available.
10.
Nguyen C, Upadhyay H, Murphy M, Borja G, Rozsahegyi E, Barnett A, et al.
Biomed Opt Express
. 2019 Feb;
10(2):789-806.
PMID: 30800515
Transmembrane voltage and intracellular calcium concentration are coupled parameters essential to the function of neurons, cardiomyocytes, and other excitable cells. Here we introduce the microscope for simultaneous optogenetic stimulation and...