Gopal K Marathe
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Explore the profile of Gopal K Marathe including associated specialties, affiliations and a list of published articles.
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32
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Recent Articles
11.
Sunitha K, Suresh P, Sebastin Santhosh M, Hemshekhar M, Thushara R, Marathe G, et al.
Int J Biol Macromol
. 2013 Jan;
55:39-46.
PMID: 23305704
Hyaluronidase inhibitors have immense applications in pathophysiological conditions associated with hyaluronan-hyaluronidase system. The present study demonstrates the inhibitory efficacy of clinically accepted antioxidant N-acetyl cysteine (NAC) against hyaluronidase of serum,...
12.
Latchoumycandane C, Marathe G, Zhang R, McIntyre T
J Biol Chem
. 2012 Mar;
287(21):17693-17705.
PMID: 22433871
TNFα generates reactive oxygen species (ROS) at the cell surface that induce cell death, but how ROS communicate to mitochondria and their specific apoptotic action(s) are both undefined. ROS oxidize...
13.
Zhou G, Marathe G, Willard B, McIntyre T
J Biol Chem
. 2011 Aug;
286(40):34820-9.
PMID: 21844189
Aspirin (acetylsalicylic acid) prophylaxis suppresses major adverse cardiovascular events, but its rapid turnover limits inhibition of platelet cyclooxygenase activity and thrombosis. Despite its importance, the identity of the enzyme(s) that...
14.
Liu J, Chen R, Marathe G, Febbraio M, Zou W, McIntyre T
Circ Res
. 2010 Dec;
108(4):469-77.
PMID: 21183738
Rationale: The phospholipid platelet-activating factor (PAF) stimulates all cells of the innate immune system and numerous cardiovascular cells. A single enzyme (plasma PAF acetylhydrolase [PAF-AH] or lipoprotein-associated phospholipase [Lp-PL]A(2)) in...
15.
Sathisha K, Khanum S, Sharath Chandra J, Ayisha F, Balaji S, Marathe G, et al.
Bioorg Med Chem
. 2010 Dec;
19(1):211-20.
PMID: 21163661
An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then...
16.
Foulks J, Marathe G, Michetti N, Stafforini D, Zimmerman G, McIntyre T, et al.
Blood
. 2009 Apr;
113(26):6699-706.
PMID: 19395675
Platelet activating factor (PAF) and PAF-like lipids induce inflammatory responses in target cells. These lipid mediators are inactivated by PAF-acetylhydrolase (PAF-AH). The PAF signaling system affects the growth of hematopoietic...
17.
Yao Y, Wolverton J, Zhang Q, Marathe G, Al-Hassani M, Konger R, et al.
J Immunol
. 2009 Feb;
182(5):2842-8.
PMID: 19234179
Recent studies have implicated the lipid mediator platelet-activating factor (PAF) in UVB-mediated systemic immunosuppression known to be a major cause for skin cancers. Previously, our group has demonstrated that UVB...
18.
Shashkin P, Brown G, Ghosh A, Marathe G, McIntyre T
J Immunol
. 2008 Aug;
181(5):3495-502.
PMID: 18714022
Platelets express TLR4 receptors, but its ligand LPS does not directly activate thrombotic functions nor, obviously, transcription by these anucleate cells. Platelets, however, store information that changes their phenotype over...
19.
Konger R, Marathe G, Yao Y, Zhang Q, Travers J
Prostaglandins Other Lipid Mediat
. 2008 Jun;
87(1-4):1-8.
PMID: 18555720
Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for...
20.
Chen J, Yang L, Foulks J, Weyrich A, Marathe G, McIntyre T
J Lipid Res
. 2007 Aug;
48(11):2365-76.
PMID: 17693621
Stimulated inflammatory cells synthesize platelet-activating factor (PAF), but lysates of these cells show little enhancement in PAF synthase activity. We show that human neutrophils contain intracellular plasma PAF acetylhydrolase (PLA2G7),...