Thomas M McIntyre
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Explore the profile of Thomas M McIntyre including associated specialties, affiliations and a list of published articles.
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92
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4124
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Recent Articles
1.
Aggarwal A, Singh T, Pham M, Godwin M, Chen R, McIntyre T, et al.
Vasc Med
. 2024 Feb;
29(2):125-134.
PMID: 38334067
Background: Postacute sequelae of COVID-19 (PASC), also referred to as "Long COVID", sometimes follows COVID-19, a disease caused by SARS-CoV-2. Although SARS-CoV-2 is well known to promote a prothrombotic state,...
2.
Aggarwal A, Singh T, Pham M, Godwin M, Chen R, McIntyre T, et al.
bioRxiv
. 2023 Dec;
PMID: 38045316
Background: Post-acute sequelae of COVID-19 (PASC), also referred as Long-COVID, sometimes follows COVID-19, a disease caused by SARS-CoV-2. While SARS-CoV-2 is well-known to promote a prothrombotic state, less is known...
3.
Cao C, Zhang L, Sorensen M, Reifenberger G, Kristensen B, McIntyre T, et al.
J Neuropathol Exp Neurol
. 2023 Sep;
82(11):921-933.
PMID: 37740942
Gain-of-function mutations in isocitrate dehydrogenase (IDH) genes result in excessive production of (D)-2-hydroxyglutarate (D-2HG) which intrinsically modifies tumor cell epigenetics and impacts surrounding noncancerous cells through nonepigenetic pathways. However, whether...
4.
Jeon H, Kim J, Cho H, Lee W, Nguyen D, Kim S, et al.
Cancer Cell
. 2023 Jul;
41(8):1480-1497.e9.
PMID: 37451272
Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably induces poorly understood global changes in GBM and its microenvironment (TME) that promote radio-resistance and recurrence. Through...
5.
Afsari F, McIntyre T
J Immunol
. 2023 Jan;
210(4):504-514.
PMID: 36602551
Gliomas expressing mutant isocitrate dehydrogenases excessively synthesize d-2-hydroxyglutarate (D2HG), suppressing immune surveillance. A portion of this D2HG is released from these tumor cells, but the way environmental D2HG inhibits lymphocyte...
6.
Chen L, Chen R, Yao M, Feng Z, Yuan G, Ye F, et al.
Sci Rep
. 2022 Dec;
12(1):21779.
PMID: 36526691
Elevated serum cytokine production in COVID-19 patients is associated with disease progression and severity. However, the stimuli that initiate cytokine production in patients remain to be fully revealed. Virus-infected cells...
7.
Sumanth M, Jacob S, Abhilasha K, Manne B, Basrur V, Lehoux S, et al.
J Leukoc Biol
. 2020 Oct;
109(5):915-930.
PMID: 33070381
Alpha-1-acid glycoprotein (AGP-1) is a positive acute phase glycoprotein with uncertain functions. Serum AGP-1 (sAGP-1) is primarily derived from hepatocytes and circulates as 12-20 different glycoforms. We isolated a glycoform...
8.
Jimenez-Pascual A, Hale J, Kordowski A, Pugh J, Silver D, Bayik D, et al.
Cancer Discov
. 2019 Aug;
9(11):1574-1589.
PMID: 31434712
Glioblastomas (GBM) are lethal brain tumors where poor outcome is attributed to cellular heterogeneity, therapeutic resistance, and a highly infiltrative nature. These characteristics are preferentially linked to GBM cancer stem...
9.
Sumanth M, Abhilasha K, Jacob S, Chaithra V, Basrur V, Willard B, et al.
Immunobiology
. 2019 Jun;
224(5):672-680.
PMID: 31239174
Alpha-1-acid glycoprotein (AGP-1) is a major positive acute phase glycoprotein with unknown functions that likely play a role in inflammation. We tested its involvement in a variety of inflammatory responses...
10.
Yue H, Febbraio M, Klenotic P, Kennedy D, Wu Y, Chen S, et al.
Arterioscler Thromb Vasc Biol
. 2018 Dec;
39(2):263-275.
PMID: 30567481
Objective- Dysregulated proliferation of vascular smooth muscle cells (VSMC) plays an essential role in neointimal hyperplasia. CD36 functions critically in atherogenesis and thrombosis. We hypothesize that CD36 regulates VSMC proliferation...