Stephen M Prescott
Overview
Explore the profile of Stephen M Prescott including associated specialties, affiliations and a list of published articles.
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52
Citations
2088
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Recent Articles
1.
Teixeira-da-Cunha M, Gomes R, Roehrs N, Bozza F, Prescott S, Stafforini D, et al.
PLoS One
. 2013 Sep;
8(9):e74567.
PMID: 24069320
Current evidence indicates that dysregulation of the host inflammatory response to infectious agents is central to the mortality of patients with sepsis. Strategies to block inflammatory mediators such as PAF...
2.
Yang J, Seo J, Nair R, Han S, Jang S, Kim K, et al.
EMBO J
. 2010 Dec;
30(1):165-80.
PMID: 21119615
Diacylglycerol (DAG) is an important lipid second messenger. DAG signalling is terminated by conversion of DAG to phosphatidic acid (PA) by diacylglycerol kinases (DGKs). The neuronal synapse is a major...
3.
Stewart P, Prescott S
J Clin Invest
. 2009 Apr;
119(4):760-3.
PMID: 19348044
COX-2 promotes colon cancer. While both nonselective NSAIDs and selective COX-2 inhibitors reduce disease burden, their adverse gastrointestinal and cardiovascular side effects limit their therapeutic use. In this issue of...
4.
Kim K, Yang J, Zhong X, Kim M, Kim Y, Lee H, et al.
EMBO J
. 2009 Feb;
28(8):1170-9.
PMID: 19229292
Diacylglycerol (DAG) is an important lipid signalling molecule that exerts an effect on various effector proteins including protein kinase C. A main mechanism for DAG removal is to convert it...
5.
McIntyre T, Prescott S, Stafforini D
J Lipid Res
. 2008 Oct;
50 Suppl:S255-9.
PMID: 18838739
Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs). These Ca2+-independent phospholipases A2 display...
6.
Al-Salihi M, Terrece Pearman A, Doan T, Reichert E, Rosenberg D, Prescott S, et al.
Cancer Lett
. 2008 Sep;
273(2):225-32.
PMID: 18790560
We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice...
7.
Prescott S, Lalouel J, Leppert M
Annu Rev Genomics Hum Genet
. 2008 Jun;
9:347-58.
PMID: 18544033
One of the early decisions in what became the Human Genome Project was to recruit families that would serve as a reference set, thereby focusing efforts to create human genetic...
8.
Miyazaki Y, Bunting M, Stafforini D, Harris E, McIntyre T, Prescott S, et al.
J Immunol
. 2007 Dec;
180(1):590-600.
PMID: 18097061
The leukocyte integrins have critical roles in host defense and inflammatory tissue injury. We found that integrin alphaDbeta2, a novel but largely uncharacterized member of this family, is restricted to...
9.
Matsumiya T, Prescott S, Stafforini D
J Immunol
. 2007 Sep;
179(7):4542-9.
PMID: 17878351
Retinoic acid inducible gene-I (RIG-I) plays important roles during innate immune responses to viral infections and as a transducer of cytokine signaling. The mechanisms of RIG-I up-regulation after cytokine stimulation...
10.
Eisinger A, Nadauld L, Shelton D, Prescott S, Stafforini D, Jones D
J Biol Chem
. 2007 Aug;
282(40):29394-400.
PMID: 17673467
Mutations in adenomatous polyposis coli (APC) underlie the earliest stages of colorectal carcinogenesis. Consequences of APC mutation include stabilization of beta-catenin, dysregulation of cyclooxygenase-2 (COX-2) expression, and loss of retinoic...