Bioorganic & Medicinal Chemistry
Overview
Bioorganic & Medicinal Chemistry is a peer-reviewed journal that focuses on the intersection of organic chemistry, biochemistry, and medicinal chemistry. It publishes original research articles, reviews, and perspectives on the design, synthesis, and evaluation of bioactive compounds for therapeutic applications. The journal covers a wide range of topics, including drug discovery, chemical biology, molecular modeling, and structure-activity relationships, making it an essential resource for researchers in the field of medicinal chemistry.
Details
Details
Abbr.
Bioorg Med Chem
Start
1993
End
Continuing
Frequency
Twelve no. a year
p-ISSN
0968-0896
e-ISSN
1464-3391
Country
United Kingdom
Language
English
Specialties
Biochemistry
Chemistry
Chemistry
Metrics
Metrics
h-index / Ranks: 848
187
SJR / Ranks: 7321
614
CiteScore / Ranks: 3428
6.40
JIF / Ranks: 2766
3.5
Recent Articles
1.
Yang X, Zheng X, Liu C, Zheng J, Dong X, Ren W, et al.
Bioorg Med Chem
. 2025 Mar;
122:118111.
PMID: 40068483
A series of ER-PROTACs compounds were designed, synthesized and tested for their ability to degrade estrogen receptor proteins and exhibit Human breast cancer cells (MCF-7) inhibition activity. Molecular docking simulations...
2.
Suresh D, Yu T, Kuppusamy R, Sabir S, Das T, Black D, et al.
Bioorg Med Chem
. 2025 Mar;
122:118137.
PMID: 40058275
Antimicrobial resistance has grown to become a global crisis consistently participating in the death of millions worldwide and accumulating costs on healthcare. Quorum sensing inhibition is a new alternative antimicrobial...
3.
Wang H, Zhu C, Swamynathan M, Rajput S, Jayanetti K, Rendina D, et al.
Bioorg Med Chem
. 2025 Mar;
122:118136.
PMID: 40058274
Prostate cancer (PCa) is one of the most common malignancies diagnosed among men and is the second leading cause of cancer-related death. Despite recent advancements in early diagnosis of PCa,...
4.
Wong S, Goh J
Bioorg Med Chem
. 2025 Mar;
122:118141.
PMID: 40058273
Fused heterocyclic imidazonaphthyridine compounds stand at the forefront of global research, captivating remarkable interest in medicinal and synthetic organic chemistry. These compounds possess a range of potent biological and pharmacological...
5.
Huang L, Liu W, Lv X, Ge X, He Z, Yang Y, et al.
Bioorg Med Chem
. 2025 Mar;
122:118145.
PMID: 40056889
a series of 6-substituted dihydrobenzophenanthridine alkaloids were synthesized by introduction of different functional groups to C-6 of dihydrobenzophenanthridine backbone. The preliminary anti-inflammatory activities of all compounds were screened by investigating...
6.
Ampomah-Wireko M, Qu Y, Li D, Wu Y, Li R, Li Y, et al.
Bioorg Med Chem
. 2025 Mar;
122:118144.
PMID: 40056888
The continuous evolution of multidrug-resistant (MDR) bacteria to existing antibiotic treatment regimens poses a serious threat to human health, so the discovery of new and potent antimicrobial drugs that are...
7.
Gadakh S, Aghav B, Teraiya N, Prajapati D, Kamdar J, Patel B, et al.
Bioorg Med Chem
. 2025 Mar;
122:118142.
PMID: 40054132
Estrogen play an important role in the development of breast cancer in menopausal women. Aromatase, an enzyme that catalyses the last step in the production of estrogen, has been identified...
8.
Huong T, Kim H, Thien N, Dung D, Kim J, Kim J, et al.
Bioorg Med Chem
. 2025 Mar;
122:118143.
PMID: 40054131
Histone deacetylases (HDACs) have emerged as compelling targets in developing anticancer therapeutics. This study outlines the development, synthesis, and biological evaluation of novel hydroxamic acid derivatives featuring a 2-oxoindoline scaffold,...
9.
Surivet J, Jacob E, Kessler M, Kohl C, Vaillant C, Bezencon O, et al.
Bioorg Med Chem
. 2025 Mar;
122:118132.
PMID: 40048842
We describe the optimization of 2-acyl-1-biarylmethylpyrazolidines, a novel class of dual orexin receptor antagonists (DORAs) designed for the treatment of sleep disorders requiring a rapid onset (<30 min) and a...
10.
Ayub Ali M, Maalouf M, Feng D, Rashid M, Gehrke N, Chhonker Y, et al.
Bioorg Med Chem
. 2025 Mar;
122:118140.
PMID: 40043324
Geranylgeranyl diphosphate synthase (GGDPS) produces the 20-carbon isoprenoid species used in protein geranylgeranylation reactions. Inhibition of GGDPS has emerged as a novel means of disrupting the activity of geranylgeranylated proteins...