Andrew S Weyrich
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Explore the profile of Andrew S Weyrich including associated specialties, affiliations and a list of published articles.
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127
Citations
6820
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Recent Articles
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Portier I, Manne B, Kosaka Y, Tolley N, Denorme F, Babur O, et al.
J Thromb Haemost
. 2024 Jun;
22(9):2576-2588.
PMID: 38849085
Background: Aging is an independent risk factor for the development of cardiovascular, thrombotic, and other chronic diseases. However, mechanisms of platelet hyperactivation in aging remain poorly understood. Objectives: Here, we...
3.
Jacob S, Kosaka Y, Bhatlekar S, Denorme F, Benzon H, Moody A, et al.
Circ Res
. 2023 Dec;
134(2):143-161.
PMID: 38156445
Background: Single-nucleotide polymorphisms linked with the rs1474868 T allele ( [mitofusin-2] T/T) in the human mitochondrial fusion protein gene are associated with reduced platelet RNA expression and platelet counts. This...
4.
Manne B, Campbell R, Bhatlekar S, Ajanel A, Denorme F, Portier I, et al.
Blood
. 2022 Aug;
140(23):2477-2489.
PMID: 35930749
The MAPK-interacting kinase (Mnk) family includes Mnk1 and Mnk2, which are phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to cellular responses by regulating messenger RNA (mRNA) translation,...
5.
Wurtzel J, Lazar S, Sikder S, Cai K, Astsaturov I, Weyrich A, et al.
PLoS One
. 2021 Dec;
16(12):e0261633.
PMID: 34936674
We investigated the contributions of platelet microRNAs (miRNAs) to the rate of growth and regulation of gene expression in primary ectopic tumors using mouse models. We previously identified an inhibitory...
6.
Guo L, Shen S, Rowley J, Tolley N, Jia W, Manne B, et al.
Blood
. 2021 Apr;
138(5):401-416.
PMID: 33895821
Circulating platelets interact with leukocytes to modulate host immune and thrombotic responses. In sepsis, platelet-leukocyte interactions are increased and have been associated with adverse clinical events, including increased platelet-T-cell interactions....
7.
Granja M, Alves L, Leardini-Tristao M, Edelman Saul M, Bortoni L, de Moraes F, et al.
J Neuroinflammation
. 2021 Feb;
18(1):60.
PMID: 33632243
Background: The term sepsis is used to designate a systemic condition of infection and inflammation associated with hemodynamic changes that result in organic dysfunction. Gestational sepsis can impair the development...
8.
Eustes A, Campbell R, Middleton E, Tolley N, Manne B, Montenont E, et al.
J Thromb Haemost
. 2021 Feb;
19(5):1319-1330.
PMID: 33587773
Background: Heparanase (HPSE) is the only known mammalian enzyme that can degrade heparan sulfate. Heparan sulfate proteoglycans are essential components of the glycocalyx, and maintain physiological barriers between the blood...
9.
Griffiths T, Page L, Weyrich A, Rondina M, Campbell R
Thromb Res
. 2020 Dec;
198:204-209.
PMID: 33360636
Background: The ability to measure changes in platelet reactivity is important to identify novel aspects of platelet biology and develop targeted therapeutics to prevent bleeding or thrombosis. Current platelet function...
10.
Sumanth M, Jacob S, Abhilasha K, Manne B, Basrur V, Lehoux S, et al.
J Leukoc Biol
. 2020 Oct;
109(5):915-930.
PMID: 33070381
Alpha-1-acid glycoprotein (AGP-1) is a positive acute phase glycoprotein with uncertain functions. Serum AGP-1 (sAGP-1) is primarily derived from hepatocytes and circulates as 12-20 different glycoforms. We isolated a glycoform...