Oxidized Glycerophosphocholines As Biologically Active Mediators for Ultraviolet Radiation-mediated Effects

Overview

Journal Prostaglandins Other Lipid Mediat

Date 2008 Jun 17

PMID 18555720

Citations 28

Authors

Raymond L Konger

Gopal K Marathe

Yongxue Yao

Qiwei Zhang

Jeffrey B Travers

Affiliations

Soon will be listed here.

Abstract

Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.

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References

Pani G, Bedogni B, Colavitti R, Anzevino R, Borrello S, Galeotti T . Cell compartmentalization in redox signaling. IUBMB Life. 2002; 52(1-2):7-16. DOI: 10.1080/15216540252774702. View

Swindells K, Rhodes L . Influence of oral antioxidants on ultraviolet radiation-induced skin damage in humans. Photodermatol Photoimmunol Photomed. 2004; 20(6):297-304. DOI: 10.1111/j.1600-0781.2004.00121.x. View

Xiang Z, Lin T, Reeves S . 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. J Neuroinflammation. 2007; 4:18. PMC: 1941731. DOI: 10.1186/1742-2094-4-18. View

Logani M, Davies R . Lipid oxidation: biologic effects and antioxidants--a review. Lipids. 1980; 15(6):485-95. DOI: 10.1007/BF02534079. View

Travers J, Huff J, Rola-Pleszczynski M, Gelfand E, Morelli J, Murphy R . Identification of functional platelet-activating factor receptors on human keratinocytes. J Invest Dermatol. 1995; 105(6):816-23. DOI: 10.1111/1523-1747.ep12326581. View

Demerjian M, Man M, Choi E, Brown B, Crumrine D, Chang S . Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model. Exp Dermatol. 2006; 15(3):154-60. DOI: 10.1111/j.1600-0625.2006.00402.x. View

Marathe G, Johnson C, Billings S, Southall M, Pei Y, Spandau D . Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. J Biol Chem. 2005; 280(42):35448-57. DOI: 10.1074/jbc.M503811200. View

Genolet R, Wahli W, Michalik L . PPARs as drug targets to modulate inflammatory responses?. Curr Drug Targets Inflamm Allergy. 2004; 3(4):361-75. DOI: 10.2174/1568010042634578. View

Marques S, Dy L, Southall M, Yi Q, Smietana E, Kapur R . The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway. J Pharmacol Exp Ther. 2002; 300(3):1026-35. DOI: 10.1124/jpet.300.3.1026. View

10.

Travers J, Edenberg H, Zhang Q, Al-Hassani M, Yi Q, Baskaran S . Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor. J Invest Dermatol. 2007; 128(2):455-60. DOI: 10.1038/sj.jid.5701083. View

11.

Gruber F, Oskolkova O, Leitner A, Mildner M, Mlitz V, Lengauer B . Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells. J Biol Chem. 2007; 282(23):16934-41. DOI: 10.1074/jbc.M702523200. View

12.

Rosen E, Spiegelman B . PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem. 2001; 276(41):37731-4. DOI: 10.1074/jbc.R100034200. View

13.

Mukhtar H . Eat plenty of green leafy vegetables for photoprotection: emerging evidence. J Invest Dermatol. 2003; 121(2):viii. DOI: 10.1046/j.1523-1747.2003.12377.x. View

14.

Stremler K, Stafforini D, Prescott S, Zimmerman G, McIntyre T . An oxidized derivative of phosphatidylcholine is a substrate for the platelet-activating factor acetylhydrolase from human plasma. J Biol Chem. 1989; 264(10):5331-4. View

15.

Paunel A, Dejam A, Thelen S, Kirsch M, Horstjann M, Gharini P . Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms. Free Radic Biol Med. 2005; 38(5):606-15. DOI: 10.1016/j.freeradbiomed.2004.11.018. View

16.

Galle J, Hansen-Hagge T, Wanner C, Seibold S . Impact of oxidized low density lipoprotein on vascular cells. Atherosclerosis. 2005; 185(2):219-26. DOI: 10.1016/j.atherosclerosis.2005.10.005. View

17.

Kremer I, Hilkens C, Koomen C, Kapsenberg M, Bos J, Teunissen M . Reduced IL-12 production by monocytes upon ultraviolet-B irradiation selectively limits activation of T helper-1 cells. J Immunol. 1996; 157(5):1913-8. View

18.

Kuenzli S, Saurat J . Peroxisome proliferator-activated receptors in cutaneous biology. Br J Dermatol. 2003; 149(2):229-36. DOI: 10.1046/j.1365-2133.2003.05532.x. View

19.

Gardner H . Oxygen radical chemistry of polyunsaturated fatty acids. Free Radic Biol Med. 1989; 7(1):65-86. DOI: 10.1016/0891-5849(89)90102-0. View

20.

Zhang Q, Yao Y, Konger R, Sinn A, Cai S, Pollok K . UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. J Invest Dermatol. 2008; 128(7):1780-7. PMC: 2643301. DOI: 10.1038/sj.jid.5701251. View