Ewa Grudzien-Nogalska
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Explore the profile of Ewa Grudzien-Nogalska including associated specialties, affiliations and a list of published articles.
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18
Citations
524
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Recent Articles
11.
Grudzien-Nogalska E, Jiao X, Song M, Hart R, Kiledjian M
RNA
. 2016 Mar;
22(5):773-81.
PMID: 26932476
Removal of the 5'-end 7-methylguanosine cap structure is a critical step in the highly regulated process of mRNA decay. The Nudix hydrolase, Dcp2, was identified as a first decapping enzyme...
12.
Grudzien-Nogalska E, Reed B, Rhoads R
J Cell Sci
. 2014 Mar;
127(Pt 10):2326-38.
PMID: 24634508
Downregulation of CPEB1, a sequence-specific RNA-binding protein, in a mouse mammary epithelial cell line (CID-9) causes epithelial-to-mesenchymal transition (EMT), based on several criteria. First, CPEB1 knockdown decreases protein levels of...
13.
Grudzien-Nogalska E, Kowalska J, Su W, Kuhn A, Slepenkov S, Darzynkiewicz E, et al.
Methods Mol Biol
. 2013 Jan;
969:55-72.
PMID: 23296927
The translational efficiency and stability of synthetic mRNA in both cultured cells and whole animals can be improved by incorporation of modified cap structures at the 5'-end. mRNAs are synthesized...
14.
Su W, Slepenkov S, Grudzien-Nogalska E, Kowalska J, Kulis M, Zuberek J, et al.
RNA
. 2011 Mar;
17(5):978-88.
PMID: 21447710
Decapping is an essential step in multiple pathways of mRNA degradation. Previously, we synthesized mRNAs containing caps that were resistant to decapping, both to dissect the various pathways for mRNA...
15.
Kowalska J, Lewdorowicz M, Zuberek J, Grudzien-Nogalska E, Bojarska E, Stepinski J, et al.
RNA
. 2008 Apr;
14(6):1119-31.
PMID: 18430890
Analogs of the mRNA cap are widely employed to study processes involved in mRNA metabolism as well as being useful in biotechnology and medicinal applications. Here we describe synthesis of...
16.
Rhoads R, Grudzien-Nogalska E
J Mammary Gland Biol Neoplasia
. 2007 Nov;
12(4):283-92.
PMID: 18026822
Studies conducted since the 1970s have revealed that the production of milk proteins in the mammary gland under the influence of lactogenic hormones (insulin, prolactin, and glucocorticoids) is regulated at...
17.
Grudzien-Nogalska E, Stepinski J, Jemielity J, Zuberek J, Stolarski R, Rhoads R, et al.
Methods Enzymol
. 2007 Oct;
431:203-27.
PMID: 17923237
Synthetic capped RNA transcripts produced by in vitro transcription in the presence of m(7)Gp(3)G have found a wide application in studying such processes as mRNA translation, pre-mRNA splicing, mRNA turnover,...
18.
Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells
Grudzien-Nogalska E, Jemielity J, Kowalska J, Darzynkiewicz E, Rhoads R
RNA
. 2007 Aug;
13(10):1745-55.
PMID: 17720878
Capped RNAs synthesized by in vitro transcription have found wide utility for studying mRNA function and metabolism and for producing proteins of interest. We characterize here a recently synthesized series...