Eranthie Weerapana
Overview
Explore the profile of Eranthie Weerapana including associated specialties, affiliations and a list of published articles.
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128
Citations
4643
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Recent Articles
1.
Alkhalaf L, Arrowsmith C, Balskus E, Bergamini G, Bhandari R, Chang C, et al.
Nat Chem Biol
. 2024 Dec;
21(1):6-15.
PMID: 39719500
No abstract available.
2.
Jackson P, Kisty E, Pradhan V, Swank C, Bohrer L, Nolan T, et al.
ACS Omega
. 2024 Oct;
9(41):42557-42570.
PMID: 39431108
One of the grand challenges in chemical biology is identifying a small-molecule modulator for all proteins within a proteome. To expand the variety and number of ligandable proteins for drug...
3.
Zhang M, Chapman M, Sarode B, Xiong B, Liang H, Chen J, et al.
Nature
. 2024 Aug;
633(8028):90-95.
PMID: 39169193
Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug. Nonoptimal potency, metabolic stability,...
4.
Bak D, Weerapana E
Methods Mol Biol
. 2024 Jul;
2839:261-289.
PMID: 39008260
Iron-sulfur (Fe-S) clusters are essential redox-active metallocofactors participating in electron transfer, radical chemistry, primary metabolism, and gene regulation. Successful trafficking and incorporation of Fe-S clusters into target proteins are critical...
5.
Fisher C, Bak D, Miller K, Washington-Hughes C, Dickfoss A, Weerapana E, et al.
J Biol Chem
. 2024 Jun;
300(8):107506.
PMID: 38944118
Iron-sulfur (Fe-S) clusters are required for essential biological pathways, including respiration and isoprenoid biosynthesis. Complex Fe-S cluster biogenesis systems have evolved to maintain an adequate supply of this critical protein...
6.
Bak D, Weerapana E
Biochim Biophys Acta Mol Cell Res
. 2024 Jun;
1871(7):119791.
PMID: 38925478
Iron‑sulfur (Fe-S) clusters, inorganic cofactors composed of iron and sulfide, participate in numerous essential redox, non-redox, structural, and regulatory biological processes within the cell. Though structurally and functionally diverse, the...
7.
Hill C, Datta S, McCurtin N, Kimball H, Kingsley M, Bayer A, et al.
Angew Chem Int Ed Engl
. 2024 Jan;
63(13):e202319579.
PMID: 38291002
A cascade of three enzymes, E1-E2-E3, is responsible for transferring ubiquitin to target proteins, which controls many different aspects of cellular signaling. The role of the E2 has been largely...
8.
Identification of Protein Targets of -Nitroso-Coenzyme A-Mediated -Nitrosation Using Chemoproteomics
Falco J, Wynia-Smith S, McCoy J, Smith B, Weerapana E
ACS Chem Biol
. 2023 Dec;
19(1):193-207.
PMID: 38159293
-Nitrosation is a cysteine post-translational modification fundamental to cellular signaling. This modification regulates protein function in numerous biological processes in the nervous, cardiovascular, and immune systems. Small molecule or protein...
9.
Peng Q, Weerapana E
Cell Chem Biol
. 2023 Dec;
31(3):550-564.e9.
PMID: 38086369
The nucleus controls cell growth and division through coordinated interactions between nuclear proteins and chromatin. Mutations that impair nuclear protein association with chromatin are implicated in numerous diseases. Covalent ligands...
10.
Loynd C, Singha Roy S, Ovalle V, Canarelli S, Mondal A, Jewel D, et al.
Nat Chem
. 2023 Dec;
16(3):389-397.
PMID: 38082177
Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis owing to its numerous attractive features, including precise control over the fundamental reaction parameters, mild reaction conditions and innate...