Benjamin F Cravatt
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Explore the profile of Benjamin F Cravatt including associated specialties, affiliations and a list of published articles.
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526
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27732
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Recent Articles
1.
Dixon C, Martin N, Niphakis M, Cravatt B, Fairn G
Cell Mol Gastroenterol Hepatol
. 2025 Mar;
:101491.
PMID: 40054525
Background And Aims: NOD2 is an intracellular innate immune receptor that detects bacterial peptidoglycan fragments. Although nominally soluble, some NOD2 is associated with the plasma membrane and endosomal compartments for...
2.
Sharma H, Bielecki M, Holm M, Thompson T, Yin Y, Cravatt J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975370
Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds ('stereoprobes') offers a versatile way to discover covalent ligands for proteins in native biological systems. Here we report the...
3.
Zhang X, Simon G, Cravatt B
Nat Chem Biol
. 2025 Jan;
PMID: 39870762
Targeted protein degradation (TPD) offers a promising approach for chemical probe and drug discovery that uses small molecules or biologics to direct proteins to the cellular machinery for destruction. Among...
4.
Li Y, Mori W, Chaudhary A, Zhao C, Yamasaki T, Zhang Z, et al.
Eur J Med Chem
. 2025 Jan;
285:117246.
PMID: 39793441
Monoacylglycerol lipase (MAGL) is a 33 kDa cytosolic serine hydrolase that is widely distributed in the central nervous system and peripheral tissues. MAGL hydrolyzes monoacylglycerols into fatty acids and glycerol,...
5.
Tang I, Nisal A, Reed A, Ware T, Johansen A, Zaki M, et al.
Sci Transl Med
. 2025 Jan;
17(779):eadp5247.
PMID: 39742503
Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder, including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase signaling. encodes a key acyltransferase in PI synthesis and...
6.
Amorello A, Chandrashekar Reddy G, Melillo B, Cravatt B, Ghosh A, Jurica M
J Biol Chem
. 2024 Dec;
301(2):108135.
PMID: 39725033
The spliceosome protein, SF3B1, is associated with U2 snRNP during early spliceosome assembly for pre-mRNA splicing. Frequent somatic mutations in SF3B1 observed in cancer necessitates the characterization of its role...
7.
Riha I, Campos M, Jin X, Wang F, Zhang C, Dunne S, et al.
RSC Med Chem
. 2024 Dec;
16(2):892-906.
PMID: 39691404
Traditional small molecule drugs often target protein activity directly, but challenges arise when proteins lack suitable functional sites. An alternative approach is targeted protein degradation (TPD), which directs proteins to...
8.
Protty M, Tyrrell V, Hajeyah A, Morgan B, Costa D, Li Y, et al.
J Lipid Res
. 2024 Dec;
66(1):100727.
PMID: 39674322
Enzymatically oxygenated phospholipids (eoxPL) from lipoxygenases (LOX) or cyclooxygenase (COX) are prothrombotic. Their generation in arterial disease, and their modulation by cardiovascular therapies is unknown. Furthermore, the Lands cycle acyl-transferases...
9.
Vazquez-Villa H, Rueda-Zubiaurre A, Fernandez D, Foronda R, Parker C, Cravatt B, et al.
Eur J Med Chem
. 2024 Dec;
283():117102.
PMID: 39616692
Honokiol is a natural product with an interesting array of biological effects, including significant anti-tumor properties. However, full exploration of its therapeutic potential is hampered by its modest pharmacokinetic profile...
10.
Scott K, Kojima H, Ropek N, Warren C, Zhang T, Hogg S, et al.
Cell Chem Biol
. 2024 Nov;
32(1):201-218.e17.
PMID: 39591969
Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric acrylamide EV96 and its analogues...