Ari J Salinger
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Explore the profile of Ari J Salinger including associated specialties, affiliations and a list of published articles.
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13
Citations
264
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Recent Articles
1.
Zhu Y, Speir M, Tan Z, Lee J, Nowell C, Chen A, et al.
Sci Adv
. 2023 Dec;
9(51):eadj1397.
PMID: 38117877
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase...
2.
Maurais A, Salinger A, Tobin M, Shaffer S, Weerapana E, Thompson P
Biochemistry
. 2021 Sep;
60(38):2902-2914.
PMID: 34491035
Citrullination is an enzyme-catalyzed post-translational modification (PTM) that is essential for a host of biological processes, including gene regulation, programmed cell death, and organ development. While this PTM is required...
3.
Tilvawala R, Nemmara V, Reyes A, Sorvillo N, Salinger A, Cherpokova D, et al.
Cell Chem Biol
. 2021 Aug;
28(12):1728-1739.e5.
PMID: 34352225
Aberrant protein citrullination is associated with many pathologies; however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in...
4.
Griffante G, Gugliesi F, Pasquero S, DellOste V, Biolatti M, Salinger A, et al.
Nat Commun
. 2021 Jun;
12(1):3910.
PMID: 34162877
Citrullination is the conversion of arginine-to-citrulline by protein arginine deiminases (PADs), whose dysregulation is implicated in the pathogenesis of various types of cancers and autoimmune diseases. Consistent with the ability...
5.
Mondal S, Gong X, Zhang X, Salinger A, Zheng L, Sen S, et al.
Angew Chem Int Ed Engl
. 2019 Jul;
58(36):12476-12480.
PMID: 31276611
Protein arginine deiminases (PADs) hydrolyze the side chain of arginine to form citrulline. Aberrant PAD activity is associated with rheumatoid arthritis, multiple sclerosis, lupus, and certain cancers. These pathologies established...
6.
Sorvillo N, Mizurini D, Coxon C, Martinod K, Tilvawala R, Cherpokova D, et al.
Circ Res
. 2019 Jun;
125(5):507-519.
PMID: 31248335
Rationale: PAD4 (peptidylarginine deiminase type IV), an enzyme essential for neutrophil extracellular trap formation (NETosis), is released together with neutrophil extracellular traps into the extracellular milieu. It citrullinates histones and...
7.
Sen S, Mondal S, Zheng L, Salinger A, Fast W, Weerapana E, et al.
ACS Chem Biol
. 2019 Apr;
14(4):613-618.
PMID: 30933557
Nicotinamide N-methyltransferase (NNMT) catalyzes the S-adenosyl-l-methionine-dependent methylation of nicotinamide to form N-methylnicotinamide. This enzyme detoxifies xenobiotics and regulates NAD biosynthesis. Additionally, NNMT is overexpressed in various cancers. Herein, we describe...
8.
Nemmara V, Tilvawala R, Salinger A, Miller L, Nguyen S, Weerapana E, et al.
ACS Chem Biol
. 2018 Jul;
13(9):2663-2672.
PMID: 30044909
Nicotinamide- N-methyltransferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. NNMT is implicated in several chronic disease conditions, including...
9.
Tilvawala R, Nguyen S, Maurais A, Nemmara V, Nagar M, Salinger A, et al.
Cell Chem Biol
. 2018 Apr;
25(6):691-704.e6.
PMID: 29628436
Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA), lupus, and cancer. Citrullinated autoantigens, a hallmark of RA, are recognized by anti-citrullinated protein antibodies (ACPAs) which are...
10.
Nemmara V, Subramanian V, Muth A, Mondal S, Salinger A, Maurais A, et al.
ACS Chem Biol
. 2018 Jan;
13(3):712-722.
PMID: 29341591
Citrullination is the post-translational hydrolysis of peptidyl-arginines to form peptidyl-citrulline, a reaction that is catalyzed by the protein arginine deiminases (PADs), a family of calcium-regulated enzymes. Aberrantly increased protein citrullination...