Eranthie Weerapana
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Explore the profile of Eranthie Weerapana including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Liu C, Liu X, Zhou M, Xia C, Lyu Y, Peng Q, et al.
J Am Chem Soc
. 2023 Aug;
145(37):20189-20195.
PMID: 37647087
Sulfation widely exists in the eukaryotic proteome. However, understanding the biological functions of sulfation in peptides and proteins has been hampered by the lack of methods to control its spatial...
12.
Chan A, Chen X, Falco J, Bak D, Weerapana E, Li B
ACS Chem Biol
. 2023 Aug;
18(9):1909-1914.
PMID: 37561838
The natural product holomycin contains a unique cyclic ene-disulfide and exhibits broad-spectrum antimicrobial activities. Reduced holomycin chelates metal ions with a high affinity and disrupts metal homeostasis in the cell....
13.
Kisty E, Saart E, Weerapana E
Antioxidants (Basel)
. 2023 May;
12(5).
PMID: 37237858
The mitochondrion is the primary energy generator of a cell and is a central player in cellular redox regulation. Mitochondrial reactive oxygen species (mtROS) are the natural byproducts of cellular...
14.
Singha Roy S, Loynd C, Jewel D, Canarelli S, Ficaretta E, Pham Q, et al.
Angew Chem Int Ed Engl
. 2023 May;
62(27):e202300961.
PMID: 37219923
We have developed a novel visible-light-catalyzed bioconjugation reaction, PhotoCLIC, that enables chemoselective attachment of diverse aromatic amine reagents onto a site-specifically installed 5-hydroxytryptophan residue (5HTP) on full-length proteins of varied...
15.
Kisty E, Falco J, Weerapana E
Cell Chem Biol
. 2023 Mar;
30(3):321-336.e6.
PMID: 36889310
Reactive oxygen species (ROS) can modulate protein function through cysteine oxidation. Identifying protein targets of ROS can provide insight into uncharacterized ROS-regulated pathways. Several redox-proteomic workflows, such as oxidative isotope-coded...
16.
Bak D, Weerapana E
Nat Chem Biol
. 2023 Jan;
19(3):356-366.
PMID: 36635565
Iron-sulfur (Fe-S) clusters are ubiquitous metallocofactors involved in redox chemistry, radical generation and gene regulation. Common methods to monitor Fe-S clusters include spectroscopic analysis of purified proteins and autoradiographic visualization...
17.
Maurais A, Weerapana E
RSC Chem Biol
. 2022 Nov;
3(10):1282-1289.
PMID: 36320891
The oxidation of methionine to methionine sulfoxide occurs under conditions of cellular oxidative stress, and modulates the function of a diverse array of proteins. Enzymatic systems that install and reverse...
18.
Perez M, Nance K, Bak D, Thalalla Gamage S, Najera S, Conte A, et al.
ACS Chem Biol
. 2022 Oct;
17(10):2789-2800.
PMID: 36190452
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a cancer predisposition syndrome driven by mutation of the tumor suppressor fumarate hydratase (FH). Inactivation of FH causes accumulation of the electrophilic...
19.
Engelberg K, Bechtel T, Michaud C, Weerapana E, Gubbels M
Nat Commun
. 2022 Aug;
13(1):4644.
PMID: 35941170
The basal complex (BC) is essential for T. gondii cell division but mechanistic details are lacking. Here we report a reciprocal proximity based biotinylation approach to map the BC's proteome....
20.
Nasuhidehnavi A, Zhao Y, Punetha A, Hemphill A, Li H, Bechtel T, et al.
Infect Immun
. 2022 Aug;
90(8):e0020522.
PMID: 35913173
The role of specific host cell surface receptors during Toxoplasma gondii invasion of host cells is poorly defined. Here, we interrogated the role of the well-known malarial invasion receptor, basigin,...