Christopher J Scott
Overview
Explore the profile of Christopher J Scott including associated specialties, affiliations and a list of published articles.
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Articles
129
Citations
2057
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Recent Articles
1.
Himawan A, Korelidou A, Perez-Moreno A, Paris J, Dominguez-Robles J, Vora L, et al.
J Mater Chem B
. 2025 Jan;
13(7):2431-2445.
PMID: 39813071
This study explores the formulation and characterization of poly(vinyl alcohol) (PVA)-based composite hydrogels synthesized through solid-state crosslinking. Comprehensive assessments were conducted on their physicochemical properties, leachables, and immunogenicity. Swelling experiments...
2.
Nawafleh H, Zeinelabdin N, Greene M, Krishnan A, Ho L, Genead M, et al.
Pharmaceuticals (Basel)
. 2024 Nov;
17(11).
PMID: 39598355
Background/objectives: Tumor microenvironmental hypoxia is an established hallmark of solid tumors. It significantly contributes to tumor aggressiveness and therapy resistance and has been reported to affect the balance of activating/inhibitory...
3.
Shajan I, Rochet L, Tracey S, Benazza R, Jackowska B, Hernandez-Alba O, et al.
Bioconjug Chem
. 2024 Sep;
PMID: 39284580
Redirecting T cells to tumor cells by bispecific antibodies is an effective approach to treat cancer, and T cell-dependent bispecific antibodies (TDBAs) are an emerging class of potent immunotherapeutic agents....
4.
Carvalho A, Greene M, Smyth P, Mutch A, McLaughlin K, Cairns L, et al.
Biomacromolecules
. 2024 Sep;
25(10):6503-6514.
PMID: 39235263
Paediatric acute myeloid leukemia (AML) is a heterogeneous hematological malignancy still heavily reliant on traditional chemotherapeutic approaches. Combination treatments have shown to be a superior approach, but their success is...
5.
Alsad A, Greene M, Tayyem M, Elmore B, Abed A, Burden R, et al.
Int J Pharm
. 2024 Aug;
664:124567.
PMID: 39127173
Bacteria can evade antimicrobial therapy by hiding inside host cells such as macrophages. Here we examine the ability of PLGA nanoparticles to deliver antibiotics to intracellular bacteria, specifically focusing upon...
6.
Vaur V, Koutsopetras I, Erb S, Jackowska B, Benazza R, Cahuzac H, et al.
Chembiochem
. 2024 May;
25(19):e202400170.
PMID: 38713134
Bispecific antibodies (bsAbs) have recently emerged as a promising platform for the treatment of several conditions, most importantly cancer. Based on the combination of two different antigen-binding motifs in a...
7.
Krishnan A, Callanan D, Sendra V, Lad A, Christian S, Earla R, et al.
Pharmaceuticals (Basel)
. 2024 Apr;
17(4).
PMID: 38675441
An inflammation-resolving polysialic acid-decorated PLGA nanoparticle (PolySia-NP) has been developed to treat geographic atrophy/age-related macular degeneration and other conditions caused by macrophage and complement over-activation. While PolySia-NPs have demonstrated pre-clinical...
8.
Abed A, Greene M, Alsad A, Lees A, Hindley A, Longley D, et al.
Mol Pharm
. 2024 Feb;
21(3):1246-1255.
PMID: 38334409
Inhibitors of the p53-MDM2 interaction such as RG7388 have been developed to exploit latent tumor suppressive properties in p53 in 50% of tumors in which p53 is wild-type. However, these...
9.
Greene M, Smyth P, English A, McLaughlin J, Bucholc M, Bailie J, et al.
Heliyon
. 2024 Feb;
10(2):e24184.
PMID: 38304848
Background: With the spread of SARS-CoV-2 impacting upon public health directly and socioeconomically, further information was required to inform policy decisions designed to limit virus spread during the pandemic. This...
10.
Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Roy Chaudhuri T, Lin Q, Stachowiak E, Rosario S, Spernyak J, Ma W, et al.
Clin Cancer Res
. 2024 Jan;
30(7):1367-1381.
PMID: 38270582
Purpose: Paracrine activation of pro-fibrotic hedgehog (HH) signaling in pancreatic ductal adenocarcinoma (PDAC) results in stromal amplification that compromises tumor drug delivery, efficacy, and patient survival. Interdiction of HH-mediated tumor-stroma...