Daniel B Longley
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Explore the profile of Daniel B Longley including associated specialties, affiliations and a list of published articles.
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104
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5775
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Recent Articles
1.
Cho S, McDonough E, Graf J, Shia J, Firat C, Urganci N, et al.
BMJ Oncol
. 2025 Jan;
3(1):e000362.
PMID: 39886119
Objective: Inducing tumour cell apoptosis is a primary objective of chemotherapy but, to date, there are no validated biomarkers of apoptosis sensitivity or resistance. Our objective was to image multiple...
2.
Campanio A, Baran M, Bowie A, Longley D, Harrison T, McGouran J
Commun Chem
. 2025 Jan;
8(1):25.
PMID: 39880982
The thiol-ene reaction between an alkene and a thiol can be exploited for selective labelling of cysteine residues in protein profiling applications. Here, we explore thiol-ene activation in systems from...
3.
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, et al.
Nucleic Acids Res
. 2024 Oct;
52(20):12534-12548.
PMID: 39351862
Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its misincorporation into DNA and inhibition of thymidylate synthase....
4.
Azimi M, Cho S, Bozkurt E, McDonough E, Kisakol B, Matveeva A, et al.
J Pathol
. 2024 Aug;
264(2):148-159.
PMID: 39092716
Colorectal cancer (CRC) is one of the most frequently occurring cancers, but prognostic biomarkers identifying patients at risk of recurrence are still lacking. In this study, we aimed to investigate...
5.
Jurisic A, Sung P, Wappett M, Daubriac J, Lobb I, Kung W, et al.
Clin Transl Med
. 2024 Apr;
14(4):e1648.
PMID: 38602256
Background: Understanding how to modulate the microenvironment of tumors that are resistant to immune checkpoint inhibitors represents a major challenge in oncology.Here we investigate the ability of USP7 inhibitors to...
6.
Kisakol B, Matveeva A, Salvucci M, Kel A, McDonough E, Ginty F, et al.
Br J Cancer
. 2024 Mar;
130(11):1809-1818.
PMID: 38532103
Background: Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in expression profiles between colon and rectal tissues. Moreover, locally advanced rectal cancers at resection often...
7.
Azimi M, Cho S, Bozkurt E, McDonough E, Kisakol B, Matveeva A, et al.
bioRxiv
. 2024 Feb;
PMID: 38352309
Colorectal cancer (CRC) is one of the most frequently occurring cancers, but prognostic biomarkers identifying patients at risk of recurrence are still lacking. In this study, we aimed to investigate...
8.
Abed A, Greene M, Alsad A, Lees A, Hindley A, Longley D, et al.
Mol Pharm
. 2024 Feb;
21(3):1246-1255.
PMID: 38334409
Inhibitors of the p53-MDM2 interaction such as RG7388 have been developed to exploit latent tumor suppressive properties in p53 in 50% of tumors in which p53 is wild-type. However, these...
9.
Holloway J, Seeley A, Cobbe N, Turkington R, Longley D, Evergren E
Cell Death Dis
. 2024 Jan;
15(1):40.
PMID: 38216558
The activation of apoptosis signalling by TRAIL (TNF-related apoptosis-inducing ligand) through receptor binding is a fundamental mechanism of cell death induction and is often perturbed in cancer cells to enhance...
10.
Sessler T, Quinn G, Wappett M, Rogan E, Sharkey D, Ahmaderaghi B, et al.
Sci Rep
. 2023 Dec;
13(1):22093.
PMID: 38086891
Kaplan-Meier (KM) survival analyses based on complex patient categorization due to the burgeoning volumes of genomic, molecular and phenotypic data, are an increasingly important aspect of the biomedical researcher's toolkit....