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Molecular Pharmaceutics

Molecular Pharmaceutics is a peer-reviewed journal that focuses on the design, development, and characterization of drug delivery systems at the molecular level. It covers a wide range of topics including drug formulation, nanomedicine, targeted drug delivery, and pharmacokinetics. With its emphasis on molecular aspects, this journal provides valuable insights into the field of pharmaceutical sciences and its impact on improving drug efficacy and patient outcomes.
Details
Abbr. Mol Pharm
Publisher American Chemical Society
Start 2004
End Continuing
Frequency Monthly, 2012-
p-ISSN 1543-8384
e-ISSN 1543-8392
Country United States
Language English
Specialty Pharmacology
Metrics
h-index / Ranks: 1303 156
SJR / Ranks: 4219 940
CiteScore / Ranks: 1714 9.20
JIF / Ranks: 1632 4.9
Recent Articles
1.
Development and Characterization of the [Lu]Lu-Labeled Anti-CDH17 Nanobody Derivative for Radioimmunotherapy in the Gastric Cancer Xenograft Model
Mao C, Li S, Fan R, Zhang J, Fan X, Shentu Z, et al.
Mol Pharm . 2025 Mar; PMID: 40088168
Cadherin 17 (CDH17) is highly expressed in digestive system cancers, and the potential of nanobodies targeting CDH17 as imaging probes and delivery vehicles for radioactive β-particles warrants exploration for their...
2.
Head-to-Head Comparison of the Performance of Highly Reactive and Polar F-Labeled Tetrazines
Hvass L, Muller M, Staudt M, Garcia-Vazquez R, Gustavsson T, Shalgunov V, et al.
Mol Pharm . 2025 Mar; PMID: 40081392
Pretargeted imaging harnessing tetrazine ligation has gained increased interest over recent years. Targeting vectors with slow pharmacokinetics may be visualized using short-lived radionuclides, such as fluorine-18 (F) for positron emission...
3.
iBCS: 4. Application of the Inhalation Biopharmaceutics Classification System to the Development of Orally Inhaled Drug Products
Forbes B, Backman P, Cabal A, Clark A, Ehrhardt C, Hastedt J, et al.
Mol Pharm . 2025 Mar; PMID: 40079210
This is the fourth paper in a series describing an inhalation biopharmaceutics classification system (iBCS), an initiative supported by the Product Quality Research Institute. The paper examines the application of...
4.
Cancer Targeting Radiopeptidomimetics in Molecular Nuclear Medicine
Satpati D
Mol Pharm . 2025 Mar; PMID: 40078059
Peptides are highly receptor-affine molecules exhibiting suitable pharmacokinetics. Additionally, low-cost production, simple protocols allowing easy modifications, and tolerance toward harsh reaction conditions make peptides ideal ligands for preparation of radiopharmaceuticals...
5.
Development and Preliminary Evaluation of a I-Labeled Radioligand ([I]iodotrazoline) for In Vitro Detection of Imidazoline-2 Binding Site in the Brain
Huang D, Guo Y, Cui M, Fu H
Mol Pharm . 2025 Mar; PMID: 40077846
Astrocytes exert multiple functions within the brain, including regulating neuroinflammation and maintaining homeostasis, and the reactive astrocytes are implicated in many neurodegenerative disorders. Imidazoline-2 binding site (IBS) has been established...
6.
Docetaxel-Loaded Electrospun Nanofibrous Mats for Local Chemotherapy Targeting Positive Surgical Margins in Prostate Cancer
Li X, Yuan K, Yin Y, Tian Y, Guo Z, Qin Z, et al.
Mol Pharm . 2025 Mar; PMID: 40073383
Positive surgical margins following radical prostatectomy significantly contribute to tumor recurrence. While systemic chemotherapy demonstrates limited efficacy in this context, local chemotherapy drug delivery systems based on nanomaterials offer promising...
7.
Is There Polyamorphism in Amorphous Indomethacin? Investigating the Physicochemical Properties of Amorphous Indomethacin with Different Thermal History
Musumeci D, Zhou J, Xie He J, Rades T, Martins I
Mol Pharm . 2025 Mar; PMID: 40073074
Polyamorphism in organic molecules is a poorly understood and controversial phenomenon related to amorphous materials. Although very few studies, including our own, have demonstrated the existence of polyamorphism in drug...
8.
Trans-Mediated, Cis-Inhibited Paradoxal Activity of Enterotoxin (c-CPE) in Modulating Epithelial Permeability
Sanchez J, Favaro M, Lopez-Laguna H, Parlade E, Di Somma A, Casanova I, et al.
Mol Pharm . 2025 Mar; PMID: 40067325
In the context of transdermal delivery, favoring the drug permeability of epithelia through convenient formulations would open new opportunities for local versus systemic drug delivery, envisaging higher patient comfort and...
9.
Development of a Radiogallium-Labeled Heterodivalent Imaging Probe Targeting Negative Charges and Integrin on the Surface of Cancer Cell Membranes
Fuchigami T, Shimo K, Hiwatashi T, Andoh Y, Munekane M, Mishiro K, et al.
Mol Pharm . 2025 Mar; PMID: 40066788
Radiopharmaceuticals targeting tumor-specific environments are powerful tools for cancer diagnosis and treatment. We previously demonstrated the considerable high tumor uptake of the cationic amphiphilic peptide, Ga-NOTA-KV6, in vivo. However, because...
10.
Ceramide Profiling of Porcine Skin and Systematic Investigation of the Impact of Sorbitan Esters (SEs) on the Barrier Function of the Skin
Schoenfelder H, Reuter M, Evers D, Herbig M, Lunter D
Mol Pharm . 2025 Mar; PMID: 40066742
The stratum corneum (SC) lipids provide the main barrier of the skin against the environment. Ceramides make up about half of the lipids by weight and are thus of particular...