James A Johnston
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Explore the profile of James A Johnston including associated specialties, affiliations and a list of published articles.
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67
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2071
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Recent Articles
1.
Mamrosh J, Sherman D, Cohen J, Johnston J, Joubert M, Li J, et al.
Sci Adv
. 2023 Jun;
9(25):eade7890.
PMID: 37352349
Peptides from degradation of intracellular proteins are continuously displayed by major histocompatibility complex (MHC) class I. To better understand origins of these peptides, we performed a comprehensive census of the...
2.
Martin A, Daris M, Johnston J, Cui J
Cytotherapy
. 2020 Dec;
23(2):131-136.
PMID: 33309258
Background Aims: To investigate the feasibility of using CD4 + T cells genetically modified to express an allo-HLA directed CAR and FOXP3 to suppress T cell proliferation and cytokine secretion...
3.
Arbelaez C, Estrada J, Gessner M, Glaus C, Morales A, Mohn D, et al.
NPJ Vaccines
. 2020 Dec;
5(1):106.
PMID: 33298945
Cancer vaccines using synthetic long peptides (SLP) targeting tumor antigens have been tested in the clinic but the outcomes have been unimpressive, perhaps because these peptides elicit predominantly CD4 T...
4.
Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, et al.
Front Pharmacol
. 2019 Mar;
10:51.
PMID: 30837866
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of the Ca-activated Cl channel,...
5.
DSouza W, Douangpanya J, Mu S, Jaeckel P, Zhang M, Maxwell J, et al.
PLoS One
. 2017 Jul;
12(7):e0180190.
PMID: 28727837
Inflammatory bowel disease (IBD) is associated with a loss of intestinal barrier function and dysregulated immune responses. It has been shown that short chain fatty acids (SCFAs) are protective in...
6.
Floudas A, Saunders S, Moran T, Schwartz C, Hams E, Fitzgerald D, et al.
J Immunol
. 2017 Jun;
199(2):707-717.
PMID: 28615416
Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. Although...
7.
Phillips J, Zhang X, Johnston J
J Vis Exp
. 2017 Apr;
(122).
PMID: 28448027
Obstructive respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) are currently treated by inhaled anti-inflammatory and bronchodilator drugs. Despite the availability of multiple treatments, both diseases are growing...
8.
Smith D, Helgason H, Sulem P, Bjornsdottir U, Lim A, Sveinbjornsson G, et al.
PLoS Genet
. 2017 Mar;
13(3):e1006659.
PMID: 28273074
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and...
9.
Doran E, Choy D, Shikotra A, Butler C, ORourke D, Johnston J, et al.
Eur Respir J
. 2016 Jun;
48(3):715-25.
PMID: 27338192
Severe asthma represents a major unmet clinical need. Eosinophilic inflammation persists in the airways of many patients with uncontrolled asthma, despite high-dose inhaled corticosteroid therapy. Suppressors of cytokine signalling (SOCS)...
10.
Spence S, Greene M, Fay F, Hams E, Saunders S, Hamid U, et al.
Sci Transl Med
. 2015 Sep;
7(303):303ra140.
PMID: 26333936
Sepsis is the most frequent cause of death in hospitalized patients, and severe sepsis is a leading contributory factor to acute respiratory distress syndrome (ARDS). At present, there is no...