Arthur Van Aerschot
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Explore the profile of Arthur Van Aerschot including associated specialties, affiliations and a list of published articles.
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106
Citations
894
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Recent Articles
11.
Pang L, Nautiyal M, De Graef S, Gadakh B, Zorzini V, Economou A, et al.
ACS Chem Biol
. 2019 Dec;
15(2):407-415.
PMID: 31869198
The pyrimidine-containing Trojan horse antibiotics albomycin and a recently discovered cytidine-containing microcin C analog target the class II seryl- and aspartyl-tRNA synthetases (serRS and aspRS), respectively. The active components of...
12.
Nautiyal M, Gadakh B, De Graef S, Pang L, Khan M, Xun Y, et al.
Antibiotics (Basel)
. 2019 Oct;
8(4).
PMID: 31600972
Emerging antibiotic resistance in pathogenic bacteria and reduction of compounds in the existing antibiotics discovery pipeline is the most critical concern for healthcare professionals. A potential solution aims to explore...
13.
De Wit F, Pillalamarri S, Sebastian-Martin A, Venkatesham A, Van Aerschot A, Debyser Z
J Biol Chem
. 2019 Jun;
294(31):11863-11875.
PMID: 31201270
Only a small portion of human immunodeficiency virus type 1 (HIV-1) particles entering the host cell results in productive infection, emphasizing the importance of identifying the functional virus population. Because...
14.
De Ruysscher D, Pang L, De Graef S, Nautiyal M, De Borggraeve W, Rozenski J, et al.
Eur J Med Chem
. 2019 May;
174:252-264.
PMID: 31048140
The superfamily of adenylate-forming enzymes all share a common chemistry. They activate a carboxylate group, on a specific substrate, by catalyzing the formation of a high energy mixed phosphoanhydride-linked nucleoside...
15.
Nautiyal M, De Graef S, Pang L, Gadakh B, Strelkov S, Weeks S, et al.
Eur J Med Chem
. 2019 Apr;
173:154-166.
PMID: 30995568
Aminoacyl-tRNA synthetases (aaRSs) catalyse the ATP-dependent coupling of an amino acid to its cognate tRNA. Being vital for protein translation aaRSs are considered a promising target for the development of...
16.
Venkatesham A, Pillalamarri S, De Wit F, Lescrinier E, Debyser Z, Van Aerschot A
Molecules
. 2019 Jan;
24(3).
PMID: 30696094
In vivo imaging of biological processes is an important asset of modern cell biology. Selectively reacting fluorophores herein are an important tool and click chemistry reactions take a large share...
17.
Zhang B, De Graef S, Nautiyal M, Pang L, Gadakh B, Froeyen M, et al.
Eur J Med Chem
. 2018 Feb;
148:384-396.
PMID: 29477072
Aminoacyl-tRNA synthetases (aaRSs) are enzymes that precisely attach an amino acid to its cognate tRNA. This process, which is essential for protein translation, is considered a viable target for the...
18.
Van Duong T, Reekmans G, Venkatesham A, Van Aerschot A, Adriaensens P, Van Humbeeck J, et al.
Mol Pharm
. 2017 Apr;
14(5):1726-1741.
PMID: 28363028
We recently found that indomethacin (IMC) can effectively act as a powerful crystallization inhibitor for polyethylene glycol 6000 (PEG) despite the fact that the absence of interactions between the drug...
19.
Serebryakova M, Tsibulskaya D, Mokina O, Kulikovsky A, Nautiyal M, Van Aerschot A, et al.
J Am Chem Soc
. 2016 Dec;
138(48):15690-15698.
PMID: 27934031
Microcin C and related antibiotics are Trojan-horse peptide-adenylates. The peptide part is responsible for facilitated transport inside the sensitive cell, where it gets processed to release a toxic warhead-a nonhydrolyzable...
20.
Venkatesham A, Saudi M, Kaptein S, Neyts J, Rozenski J, Froeyen M, et al.
Eur J Med Chem
. 2016 Oct;
126:101-109.
PMID: 27750144
Previous efforts led to dicarboxamide derivatives like 1.3, comprising either an imidazole, pyrazine or fenyl ring as the central scaffold, with many congeners displaying strong inhibitory effects against dengue virus...