European Journal of Medicinal Chemistry
Overview
The European Journal of Medicinal Chemistry is a renowned scientific journal that publishes cutting-edge research in the field of medicinal chemistry. It focuses on the design, synthesis, and evaluation of novel compounds with potential therapeutic applications. The journal provides a platform for scientists and researchers to share their findings, advancements, and insights in drug discovery and development, aiming to contribute to the improvement of human health.
Details
Details
Metrics
Metrics
h-index / Ranks: 693
203
SJR / Ranks: 3014
1151
CiteScore / Ranks: 934
12.10
JIF / Ranks: 910
6.7
Recent Articles
1.
Laghezza A, Falbo E, Gilardi F, Thomas A, Brunetti L, Leuci R, et al.
Eur J Med Chem
. 2025 Mar;
289:117494.
PMID: 40088662
A rational drug design approach led to the synthesis of three pairs of enantiomers derived from the peroxisome proliferator-activated receptor (PPAR) pan agonist AL29-26, identifying (S)-2 as a potent and...
2.
Wen Q, He Y, Chi J, Wang L, Ren Y, Niu X, et al.
Eur J Med Chem
. 2025 Mar;
289:117496.
PMID: 40088661
Antimicrobial resistance poses an urgent threat to global health, underscoring the critical need for new antibacterial drugs. Ciprofloxacin, a third-generation quinolone antibiotic, is used to treat different types of bacterial...
3.
Xiong X, Zhu X, Yu D, Huang Q, Wu X, Tan G, et al.
Eur J Med Chem
. 2025 Mar;
289:117498.
PMID: 40088660
Alkaloids are typically found in plants and certain animals, but are rare in actinomycetes. Recently, there have been significant advances in the discovery of bacterial alkaloids and the elucidation of...
4.
de Oliveira Rios E, Albino S, Olimpio de Moura R, Nascimento I
Eur J Med Chem
. 2025 Mar;
289:117500.
PMID: 40085977
Leishmaniasis is a severe disease and results in high mortality rates. Despite this, there are few drugs to treat and with various limitations such as toxicity and resistance, which justifies...
5.
Huang Y, Zheng D, Li C, Pi X, Wang S, Li Z, et al.
Eur J Med Chem
. 2025 Mar;
289:117487.
PMID: 40085976
Immunotherapy targeting the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway has achieved remarkable clinical success, but there is a shortage of effective approaches for screening suitable patients. Recently developed...
6.
Wei L, You Y, Hu Y, Wang K, Zhao H, Cheng Y, et al.
Eur J Med Chem
. 2025 Mar;
289:117490.
PMID: 40085975
Pseudorabies virus (PRV) is a significant pathogen impacting swine health and poses high zoonotic risks to humans. Effective antiviral treatments for PRV remain limited, underscoring the need for novel therapeutic...
7.
Zhou H, Zhu C, Li Y, Zhao F, Feng Q, Liu S, et al.
Eur J Med Chem
. 2025 Mar;
289:117485.
PMID: 40081104
Although phototherapy shows great potential as a safe ablative modality for treatment of cutaneous melanoma, there remain serious flaws restricting its therapeutic outcomes, such as cellular resistance against apoptosis, tumor...
8.
Zhang J, Yin Y, Wang B, Chen J, Yang H, Li T, et al.
Eur J Med Chem
. 2025 Mar;
289:117442.
PMID: 40081103
Acquired resistance to tyrosine kinase inhibitors (TKIs) has become a significant challenge in cancer therapy, underscoring the urgent need for developing alternative therapeutic targets to relieve it. Targeting TGF-β signaling...
9.
Wu S, Zhao P, Hou Y, He L, Wang Z, Yang D, et al.
Eur J Med Chem
. 2025 Mar;
289:117492.
PMID: 40081102
FMS-like tyrosine kinase 3 (FLT3) is an ideal drug target for the treatment of acute myeloid leukemia (AML). Although several FLT3 inhibitors have been approved or evaluated in clinical trials,...
10.
Chen S, Qu Y, Li R, Ampomah-Wireko M, Kong H, Li D, et al.
Eur J Med Chem
. 2025 Mar;
289:117484.
PMID: 40081101
Developing innovative antimicrobial agents is essential in the fight against drug-resistant bacteria, as well as biofilms and persistent bacteria. In this study, four series of amphiphilic cephalosporin derivatives were synthesized....