Konstantin Severinov
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Explore the profile of Konstantin Severinov including associated specialties, affiliations and a list of published articles.
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304
Citations
10244
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Recent Articles
1.
Gilep K, Bikmetov D, Popov A, Rusanova A, Tagami S, Dubiley S, et al.
mBio
. 2025 Mar;
:e0000325.
PMID: 40052803
Importance: Genes encoding virulence-associated protein D (VapD) homologs are found in many pathogens such as , , and . There are many indications that VapD proteins contribute to virulence, even...
2.
Drobiazko A, Adams M, Skutel M, Potekhina K, Kotovskaya O, Trofimova A, et al.
Nat Commun
. 2025 Feb;
16(1):1825.
PMID: 39979294
Anti-phage systems of the BREX (BacteRiophage EXclusion) superfamily rely on site-specific epigenetic DNA methylation to discriminate between the host and invading DNA. We demonstrate that in Type I BREX systems,...
3.
Iarema P, Kotovskaya O, Skutel M, Drobiazko A, Moiseenko A, Sokolova O, et al.
Viruses
. 2025 Jan;
16(12.
PMID: 39772213
Using BW25113 as a host, we isolated a novel lytic phage from the commercial poly-specific therapeutic phage cocktail Sextaphage (Microgen, Russia). We provide genetic and phenotypic characterization of the phage...
4.
Luo S, Li X, Gong X, Kulikovsky A, Qu F, Beis K, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
122(1):e2319483121.
PMID: 39739799
Infections caused by gram-negative pathogens continue to be a major risk to human health because of the innate antibiotic resistance endowed by their unique cell membrane architecture. Nature has developed...
5.
Arseniev A, Panfilov M, Pobegalov G, Potyseva A, Pavlinova P, Yakunina M, et al.
Nucleic Acids Res
. 2024 Dec;
53(1.
PMID: 39656915
Antibiotic streptolydigin (Stl) inhibits bacterial transcription by blocking the trigger loop folding in the active center of RNA polymerase (RNAP), which is essential for catalysis. We use acoustic force spectroscopy...
6.
Burman N, Belukhina S, Depardieu F, Wilkinson R, Skutel M, Santiago-Frangos A, et al.
Nature
. 2024 Dec;
636(8043):E8.
PMID: 39633059
No abstract available.
7.
Galivondzhyan A, Sutormin D, Panteleev V, Kulbachinskiy A, Severinov K
Biochem Soc Trans
. 2024 Oct;
52(5):2157-2166.
PMID: 39446311
Argonaute proteins are programmable nucleases found in all domains of life. Eukaryotic argonautes (eAgos) participate in genetic regulation, antiviral response, and transposon silencing during RNA interference. Prokaryotic argonautes (pAgos) are...
8.
Kolesnik M, Pavlov C, Demkina A, Samolygo A, Karneyeva K, Trofimova A, et al.
Viruses
. 2024 Sep;
16(9).
PMID: 39339886
Highly diverse phages infecting thermophilic bacteria of the genus have been isolated over the years from hot springs around the world. Many of these phages are unique, rely on highly...
9.
Burman N, Belukhina S, Depardieu F, Wilkinson R, Skutel M, Santiago-Frangos A, et al.
Nature
. 2024 Aug;
634(8033):424-431.
PMID: 39111359
Viruses compete with each other for limited cellular resources, and some deliver defence mechanisms that protect the host from competing genetic parasites. The phage antirestriction induced system (PARIS) is a...
10.
Kozlova S, Morozova N, Ispolatov Y, Severinov K
mBio
. 2024 Jul;
15(8):e0140824.
PMID: 38980007
Plasmid-borne Type II restriction-modification (RM) systems mediate post-segregational killing (PSK). PSK is thought to be caused by the dilution of restriction and modification enzymes during cell division, resulting in accumulation...