Wulf Blankenfeldt
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Explore the profile of Wulf Blankenfeldt including associated specialties, affiliations and a list of published articles.
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120
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2289
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Recent Articles
1.
Wandera K, Schmelz S, Migur A, Kibe A, Lukat P, Achmedov T, et al.
Mol Cell
. 2025 Feb;
PMID: 39965569
Anti-CRISPR proteins (Acrs) inhibit CRISPR-Cas immune defenses, with almost all known Acrs acting on the Cas nuclease-CRISPR (cr)RNA ribonucleoprotein (RNP) complex. Here, we show that AcrVIB1 from Riemerella anatipestifer, the...
2.
Zhao M, Chen C, Blankenfeldt W, Pessler F, Bussow K
Sci Rep
. 2025 Feb;
15(1):5076.
PMID: 39934230
cis-Aconitate decarboxylase (ACOD1, CAD, IRG1) catalyses the synthesis of itaconic acid in activated myeloid cells such as macrophages. Several histidine residues in the active site bind the substrate and enable...
3.
Bdeir N, Luddecke T, Maass H, Schmelz S, Rand U, Jacobsen H, et al.
Nat Commun
. 2025 Jan;
16(1):809.
PMID: 39827186
The recently detected Omicron BA.2.86 lineage contains more than 30 amino acid mutations relative to BA.2. BA.2.86 and its JN.1 derivative evade neutralization by serum antibodies of fully vaccinated individuals....
4.
Fenwick M, Pierce P, Abendroth J, Barrett K, Barrett L, Bowatte K, et al.
Commun Biol
. 2024 Dec;
7(1):1622.
PMID: 39639052
Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III). It...
5.
Kaspar F, Eilert L, Staar S, Oung S, Wolter M, Ganskow C, et al.
Angew Chem Int Ed Engl
. 2024 Oct;
63(46):e202412597.
PMID: 39359010
Although ethers are common in secondary natural products, they are an underrepresented functional group in primary metabolism. As such, there are comparably few enzymes capable of constructing ether bonds in...
6.
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, et al.
ACS Omega
. 2024 Sep;
9(36):38160-38168.
PMID: 39281890
In the search for new antitubercular compounds, we leveraged target-directed dynamic combinatorial chemistry (tdDCC) as an efficient hit-identification method. In tdDCC, the target selects its own binders from a dynamic...
7.
Piskol F, Lukat P, Kaufhold L, Heger A, Blankenfeldt W, Jahn D, et al.
Front Microbiol
. 2024 Aug;
15:1446595.
PMID: 39206375
is an opportunistic human pathogen which can use host-derived L-carnitine as sole carbon and energy source. Recently, an L-carnitine transporter (Aci1347) and a specific monooxygense (CntA/CntB) for the intracellular cleavage...
8.
Baumgarten J, Schneider P, Thiemann M, Zimmermann M, Diederich C, Blankenfeldt W, et al.
ChemMedChem
. 2024 Aug;
19(24):e202400466.
PMID: 39163032
The phenazine pyocyanin is an important virulence factor of the pathogen Pseudomonas aeruginosa, which is on the WHO list of antibiotic resistant "priority pathogens". In this study the isomerase PhzF,...
9.
Abdelsamie A, Hamed M, Schutz C, Rohrig T, Kany A, Schmelz S, et al.
Eur J Med Chem
. 2024 Jul;
276:116685.
PMID: 39042991
Pseudomonas aeruginosa causes life-threatening infections especially in hospitalized patients and shows an increasing resistance to established antibiotics. A process known as quorum sensing (QS) enables the pathogen to collectively adapt...
10.
Behlendorf C, Diwo M, Neumann-Schaal M, Fuchs M, Korner D, Jansch L, et al.
PNAS Nexus
. 2024 Jul;
3(7):pgae249.
PMID: 38979079
Stickland fermentation, the coupled oxidation and reduction of amino acid pairs, is a major pathway for obtaining energy in the nosocomial bacterium . D-proline is the preferred substrate for the...