Peer Lukat
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Explore the profile of Peer Lukat including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
294
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0
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Recent Articles
1.
Wandera K, Schmelz S, Migur A, Kibe A, Lukat P, Achmedov T, et al.
Mol Cell
. 2025 Feb;
PMID: 39965569
Anti-CRISPR proteins (Acrs) inhibit CRISPR-Cas immune defenses, with almost all known Acrs acting on the Cas nuclease-CRISPR (cr)RNA ribonucleoprotein (RNP) complex. Here, we show that AcrVIB1 from Riemerella anatipestifer, the...
2.
Fenwick M, Pierce P, Abendroth J, Barrett K, Barrett L, Bowatte K, et al.
Commun Biol
. 2024 Dec;
7(1):1622.
PMID: 39639052
Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III). It...
3.
Piskol F, Lukat P, Kaufhold L, Heger A, Blankenfeldt W, Jahn D, et al.
Front Microbiol
. 2024 Aug;
15:1446595.
PMID: 39206375
is an opportunistic human pathogen which can use host-derived L-carnitine as sole carbon and energy source. Recently, an L-carnitine transporter (Aci1347) and a specific monooxygense (CntA/CntB) for the intracellular cleavage...
4.
Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, et al.
Nat Commun
. 2024 Jan;
15(1):791.
PMID: 38278788
DNA polymerase III sliding clamp (DnaN) was recently validated as a new anti-tuberculosis target employing griselimycins. Three (2 S,4 R)-4-methylproline moieties of methylgriselimycin play significant roles in target binding and...
5.
Gorelik T, Lukat P, Kleeberg C, Blankenfeldt W, Mueller R
Acta Crystallogr A Found Adv
. 2023 Oct;
79(Pt 6):504-514.
PMID: 37855135
The resolution of 3D electron diffraction (ED) data of small-molecule crystals is often relatively poor, due to either electron-beam radiation damage during data collection or poor crystallinity of the material....
6.
Hofler S, Lukat P, Blankenfeldt W, Carlomagno T
Sci Rep
. 2021 Sep;
11(1):17561.
PMID: 34475498
Box C/D ribonucleoprotein complexes are RNA-guided methyltransferases that methylate the ribose 2'-OH of RNA. The central 'guide RNA' has box C and D motifs at its ends, which are crucial...
7.
Schotte C, Lukat P, Deuschmann A, Blankenfeldt W, Cox R
Angew Chem Int Ed Engl
. 2021 Jun;
60(37):20308-20312.
PMID: 34180566
The non-canonical terpene cyclase AsR6 is responsible for the formation of 2E,6E,9E-humulene during the biosynthesis of the tropolone sesquiterpenoid (TS) xenovulene A. The structures of unliganded AsR6 and of AsR6...
8.
Schubert M, Nimtz M, Bertoglio F, Schmelz S, Lukat P, van den Heuvel J
Methods Mol Biol
. 2021 May;
2305:129-140.
PMID: 33950387
The expression of mammalian recombinant proteins in insect cell lines using transient-plasmid-based gene expression enables the production of high-quality protein samples. Here, the procedure for virus-free transient gene expression (TGE)...
9.
Hofler S, Lukat P, Blankenfeldt W, Carlomagno T
RNA
. 2021 Jan;
27(4):496-512.
PMID: 33483369
Ribosomal RNA (rRNA) carries extensive 2'-O-methyl marks at functionally important sites. This simple chemical modification is thought to confer stability, promote RNA folding, and contribute to generate a heterogenous ribosome...
10.
Chaoprasid P, Lukat P, Muhlen S, Heidler T, Gazdag E, Dong S, et al.
EMBO J
. 2021 Jan;
40(4):e105202.
PMID: 33410511
Cytotoxic necrotizing factors (CNFs) are bacterial single-chain exotoxins that modulate cytokinetic/oncogenic and inflammatory processes through activation of host cell Rho GTPases. To achieve this, they are secreted, bind surface receptors...