Wulf Blankenfeldt
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Explore the profile of Wulf Blankenfeldt including associated specialties, affiliations and a list of published articles.
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120
Citations
2289
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Recent Articles
11.
Mingers T, Barthels S, Mass V, Borrero-de Acuna J, Biedendieck R, Cooke A, et al.
Front Microbiol
. 2024 Mar;
15:1378989.
PMID: 38544863
Nature utilizes three distinct pathways to synthesize the essential enzyme cofactor heme. The coproporphyrin III-dependent pathway, predominantly present in , employs an oxygen-dependent coproporphyrinogen III oxidase (CgoX) that converts coproporphyrinogen...
12.
Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, et al.
Nat Commun
. 2024 Jan;
15(1):791.
PMID: 38278788
DNA polymerase III sliding clamp (DnaN) was recently validated as a new anti-tuberculosis target employing griselimycins. Three (2 S,4 R)-4-methylproline moieties of methylgriselimycin play significant roles in target binding and...
13.
Truthe S, Klassert T, Schmelz S, Jonigk D, Blankenfeldt W, Slevogt H
J Innate Immun
. 2024 Jan;
16(1):105-132.
PMID: 38232720
Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of atherosclerosis. Recent research...
14.
Hiller M, Diwo M, Wamp S, Gutsmann T, Lang C, Blankenfeldt W, et al.
Mol Microbiol
. 2023 Dec;
121(3):497-512.
PMID: 38130174
Legionella pneumophila, the causative agent of a life-threatening pneumonia, intracellularly replicates in a specialized compartment in lung macrophages, the Legionella-containing vacuole (LCV). Secreted proteins of the pathogen govern important steps...
15.
Gorelik T, Lukat P, Kleeberg C, Blankenfeldt W, Mueller R
Acta Crystallogr A Found Adv
. 2023 Oct;
79(Pt 6):504-514.
PMID: 37855135
The resolution of 3D electron diffraction (ED) data of small-molecule crystals is often relatively poor, due to either electron-beam radiation damage during data collection or poor crystallinity of the material....
16.
Kirchenwitz M, Halfen J, von Peinen K, Prettin S, Kollasser J, Zur Lage S, et al.
Eur J Cell Biol
. 2023 Sep;
102(4):151358.
PMID: 37703749
Salmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking...
17.
Chen F, Yalcin I, Zhao M, Chen C, Blankenfeldt W, Pessler F, et al.
Sci Rep
. 2023 Jun;
13(1):10360.
PMID: 37365251
cis-Aconitate decarboxylase (ACOD1, IRG1) converts cis-aconitate to the immunomodulatory and antibacterial metabolite itaconate. Although the active site residues of human and mouse ACOD1 are identical, the mouse enzyme is about...
18.
Schwanke H, Magalhaes V, Schmelz S, Wyler E, Hennig T, Gunther T, et al.
J Virol
. 2023 Jun;
97(6):e0040023.
PMID: 37289084
Induction of type I interferon (IFN) gene expression is among the first lines of cellular defense a virus encounters during primary infection. We previously identified the tegument protein M35 of...
19.
Hamed M, Abdelsamie A, Rox K, Schutz C, Kany A, Rohrig T, et al.
Adv Sci (Weinh)
. 2023 Jan;
10(5):e2204443.
PMID: 36596691
Pseudomonas aeruginosa (PA) is an opportunistic human pathogen, which is involved in a wide range of dangerous infections. It develops alarming resistances toward antibiotic treatment. Therefore, alternative strategies, which suppress...
20.
Borgert S, Henke S, Witzgall F, Schmelz S, Zur Lage S, Hotop S, et al.
Nat Commun
. 2022 Dec;
13(1):7402.
PMID: 36456567
Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three intertwined quorum sensing systems control virulence...