W David Nes
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Explore the profile of W David Nes including associated specialties, affiliations and a list of published articles.
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76
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1758
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Recent Articles
1.
Nes W, Chaudhuri M, Leaver D
Biomolecules
. 2024 Mar;
14(3).
PMID: 38540670
Sterol biosynthesis via the mevalonate-isoprenoid pathway produces ergosterol (24β-methyl cholesta-5,7-dienol) necessary for growth in a wide-range of eukaryotic pathogenic organisms in eukaryotes, including the fungi, trypanosomes and amoebae, while their...
2.
Madan B, Wadia S, Patnaik S, Harmston N, Tan E, Tan I, et al.
J Clin Invest
. 2024 Mar;
134(6).
PMID: 38488003
Wnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a...
3.
Chaudhuri M, Singha U, Vanderloop B, Tripathi A, Nes W
Molecules
. 2022 Jul;
27(13).
PMID: 35807334
, the causative agent for human African trypanosomiasis, is an emerging ergosterol-dependent parasite that produces chokepoint enzymes, sterol methyltransferases (SMT), not synthesized in their animal hosts that can regulate cell...
4.
Hargrove T, Wawrzak Z, Rachakonda G, Nes W, Villalta F, Guengerich F, et al.
J Med Chem
. 2021 Nov;
64(23):17511-17522.
PMID: 34842434
is the protozoan pathogen that causes primary amoebic meningoencephalitis (PAM), with the death rate exceeding 97%. The amoeba makes sterols and can be targeted by sterol biosynthesis inhibitors. Here, we...
5.
Madan B, Virshup D, Nes W, Leaver D
Biochem Pharmacol
. 2021 May;
196:114611.
PMID: 34010597
Cholesterol biosynthesis, primarily associated with eukaryotes, occurs as an essential component of human metabolism with biosynthetic deregulation a factor in cancer viability. The segment that partitions between squalene and the...
6.
Zu P, Koch H, Schwery O, Pironon S, Phillips C, Ondo I, et al.
New Phytol
. 2021 Jan;
230(3):1169-1184.
PMID: 33484583
Phytosterols are primary plant metabolites that have fundamental structural and regulatory functions. They are also essential nutrients for phytophagous insects, including pollinators, that cannot synthesize sterols. Despite the well-described composition...
7.
Zhou W, Fisher P, Vanderloop B, Shen Y, Shi H, Maldonado A, et al.
J Lipid Res
. 2019 Sep;
61(2):192-204.
PMID: 31548366
Primitive sterol evolution plays an important role in fossil record interpretation and offers potential therapeutic avenues for human disease resulting from nematode infections. Recognizing that C4-methyl stenol products [8(14)-lophenol] can...
8.
Warrilow A, Parker J, Price C, Rolley N, Nes W, Kelly D, et al.
Int J Antimicrob Agents
. 2019 Jul;
54(4):449-455.
PMID: 31310805
Here we report the first evaluation of isavuconazole inhibition of Aspergillus fumigatus CYP51 and thus sterol biosynthesis in the fungus. Voriconazole and isavuconazole both bound tightly to recombinant A. fumigatus...
9.
Zhou W, Ramos E, Zhu X, Fisher P, Kidane M, Vanderloop B, et al.
J Lipid Res
. 2019 Feb;
60(5):981-994.
PMID: 30709898
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of...
10.
Friggeri L, Hargrove T, Rachakonda G, Blobaum A, Fisher P, de Oliveira G, et al.
J Med Chem
. 2018 Nov;
61(23):10910-10921.
PMID: 30451500
Sterol 14α-demethylases (CYP51) are cytochrome P450 enzymes essential for sterol biosynthesis in eukaryotes and therapeutic targets for antifungal azoles. Multiple attempts to repurpose antifungals for treatment of human infections with...