W David Nes
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Explore the profile of W David Nes including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Hargrove T, Wawrzak Z, Fisher P, Child S, Nes W, Guengerich F, et al.
J Biol Chem
. 2018 Oct;
293(50):19344-19353.
PMID: 30327430
Sterol 14α-demethylases (CYP51s) are phylogenetically the most conserved cytochromes P450, and their three-step reaction is crucial for biosynthesis of sterols and serves as a leading target for clinical and agricultural...
12.
Zhou W, Debnath A, Jennings G, Hahn H, Vanderloop B, Chaudhuri M, et al.
PLoS Pathog
. 2018 Sep;
14(9):e1007245.
PMID: 30212566
Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans. The high mortality rate of PAM...
13.
Zhou W, Warrilow A, Thomas C, Ramos E, Parker J, Price C, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2018 Jul;
1863(10):1164-1178.
PMID: 30044954
The sterol metabolome of Acanthamoeba castellanii (Ac) yielded 25 sterols. Substrate screening of cloned AcCYP51 revealed obtusifoliol as the natural substrate which converts to ∆-sterol (<95%). The combination of [H-methyl]methionine...
14.
Friggeri L, Hargrove T, Wawrzak Z, Blobaum A, Rachakonda G, Lindsley C, et al.
J Med Chem
. 2018 Jun;
61(13):5679-5691.
PMID: 29894182
Because of the increase in the number of immunocompromised patients, the incidence of invasive fungal infections is growing, but the treatment efficiency remains unacceptably low. The most potent clinical systemic...
15.
Debnath A, Calvet C, Jennings G, Zhou W, Aksenov A, Luth M, et al.
PLoS Negl Trop Dis
. 2017 Dec;
11(12):e0006104.
PMID: 29284029
Primary Amoebic Meningoencephalitis (PAM) is caused by Naegleria fowleri, a free-living amoeba that occasionally infects humans. While considered "rare" (but likely underreported) the high mortality rate and lack of established...
16.
Kidane M, Vanderloop B, Zhou W, Thomas C, Ramos E, Singha U, et al.
J Lipid Res
. 2017 Oct;
58(12):2310-2323.
PMID: 29042405
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24-/28-methylases...
17.
Warrilow A, Parker J, Price C, Garvey E, Hoekstra W, Schotzinger R, et al.
Antimicrob Agents Chemother
. 2017 May;
61(7).
PMID: 28483956
Prior to characterization of antifungal inhibitors that target CYP51, CYP51 was expressed in , purified, and characterized. CYP51 bound lanosterol, obtusifoliol, and eburicol with similar affinities (dissociation constant [ ]...
18.
Miller M, Patkar P, Singha U, Chaudhuri M, Nes W
Biochim Biophys Acta Mol Cell Biol Lipids
. 2016 Dec;
1862(3):305-313.
PMID: 27939999
A new class of steroidal therapeutics based on phylogenetic-guided design of covalent inhibitors that target parasite-specific enzymes of ergosterol biosynthesis is shown to prevent growth of the protozoan-Trypanosoma brucei, responsible...
19.
Warrilow A, Price C, Parker J, Rolley N, Smyrniotis C, Hughes D, et al.
Sci Rep
. 2016 Jun;
6:27690.
PMID: 27291783
Malassezia globosa cytochromes P450 CYP51 and CYP5218 are sterol 14α-demethylase (the target of azole antifungals) and a putative fatty acid metabolism protein (and a potential azole drug target), respectively. Lanosterol,...
20.
Warrilow A, Parker J, Price C, Nes W, Garvey E, Hoekstra W, et al.
Antimicrob Agents Chemother
. 2016 May;
60(8):4530-8.
PMID: 27161631
Cryptococcosis is a life-threatening disease often associated with HIV infection. Three Cryptococcus species CYP51 enzymes were purified and catalyzed the 14α-demethylation of lanosterol, eburicol, and obtusifoliol. The investigational agent VT-1129...