Michael R Waterman
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Explore the profile of Michael R Waterman including associated specialties, affiliations and a list of published articles.
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94
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3127
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Recent Articles
1.
Lamb D, Hargrove T, Zhao B, Wawrzak Z, Goldstone J, Nes W, et al.
Mol Biol Evol
. 2020 Oct;
38(3):952-967.
PMID: 33031537
Sterol biosynthesis, primarily associated with eukaryotic kingdoms of life, occurs as an abbreviated pathway in the bacterium Methylococcus capsulatus. Sterol 14α-demethylation is an essential step in this pathway and is...
2.
Hargrove T, Wawrzak Z, Fisher P, Child S, Nes W, Guengerich F, et al.
J Biol Chem
. 2018 Oct;
293(50):19344-19353.
PMID: 30327430
Sterol 14α-demethylases (CYP51s) are phylogenetically the most conserved cytochromes P450, and their three-step reaction is crucial for biosynthesis of sterols and serves as a leading target for clinical and agricultural...
3.
Lepesheva G, Friggeri L, Waterman M
Parasitology
. 2018 Apr;
145(14):1820-1836.
PMID: 29642960
The efficiency of treatment of human infections with the unicellular eukaryotic pathogens such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates from nosocomial fungemia in critically...
4.
Wang C, Pallan P, Zhang W, Lei L, Yoshimoto F, Waterman M, et al.
J Biol Chem
. 2017 May;
292(26):10767-10778.
PMID: 28539365
Cytochrome P450 (P450, CYP) 21A2 is the major steroid 21-hydroxylase, converting progesterone to 11-deoxycorticosterone and 17α-hydroxyprogesterone (17α-OH-progesterone) to 11-deoxycortisol. More than 100 variants give rise to congenital adrenal hyperplasia (CAH)....
5.
Hargrove T, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya E, Hiebert S, et al.
J Lipid Res
. 2016 Jun;
57(8):1552-63.
PMID: 27313059
Rapidly multiplying cancer cells synthesize greater amounts of cholesterol to build their membranes. Cholesterol-lowering drugs (statins) are currently in clinical trials for anticancer chemotherapy. However, given at higher doses, statins...
6.
Guengerich F, Waterman M, Egli M
Trends Pharmacol Sci
. 2016 Jun;
37(8):625-640.
PMID: 27267697
Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic activities are important issues in areas...
7.
Goldstone J, Sundaramoorthy M, Zhao B, Waterman M, Stegeman J, Lamb D
Mol Phylogenet Evol
. 2015 Oct;
94(Pt B):676-687.
PMID: 26432395
Biosynthesis of steroid hormones in vertebrates involves three cytochrome P450 hydroxylases, CYP11A1, CYP17A1 and CYP19A1, which catalyze sequential steps in steroidogenesis. These enzymes are conserved in the vertebrates, but their...
8.
Pallan P, Lei L, Wang C, Waterman M, Guengerich F, Egli M
Mol Endocrinol
. 2015 Jul;
29(9):1375-84.
PMID: 26172259
Cytochrome P450 21A2 is a key player in steroid 21-hydroxylation and converts progesterone to 11-deoxycorticosterone and 17α-hydroxy progesterone to 11-deoxycortisol. More than 100 mutations in P450 21A2 have been established...
9.
Lepesheva G, Hargrove T, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, et al.
J Infect Dis
. 2015 Apr;
212(9):1439-48.
PMID: 25883390
Sterol 14α-demethylases (CYP51) are the enzymes essential for sterol biosynthesis. They serve as clinical targets for antifungal azoles and are considered as targets for treatment of human Trypanosomatidae infections. Recently,...
10.
Pallan P, Wang C, Lei L, Yoshimoto F, Auchus R, Waterman M, et al.
J Biol Chem
. 2015 Apr;
290(21):13128-43.
PMID: 25855791
Cytochrome P450 (P450) 21A2 is the major steroid 21-hydroxylase, and deficiency of this enzyme is involved in ∼95% of cases of human congenital adrenal hyperplasia, a disorder of adrenal steroidogenesis....