Steven L Kelly
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Explore the profile of Steven L Kelly including associated specialties, affiliations and a list of published articles.
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109
Citations
4205
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Recent Articles
1.
Murarka V, Kim J, Lamb D, Kelly S, Poulos T, Follmer A
J Biol Chem
. 2025 Jan;
301(3):108185.
PMID: 39814230
NysL, a cytochrome P450 monooxygenase from the Gram-positive bacterium Streptomyces noursei, catalyzes the C10 hydroxylation of 10-deoxynystain to nystatin A, a clinically important antifungal. In this study, we present the...
2.
Ollinger T, Zarnowski R, Parker J, Kelly S, Andes D, Stamnes M, et al.
Antimicrob Agents Chemother
. 2024 Dec;
69(2):e0129424.
PMID: 39714155
is the second most common cause of invasive candidiasis and is widely known to have reduced susceptibility to fluconazole relative to many other spp. Upc2A is a transcription factor that...
3.
Hargrove T, Lamb D, Wawrzak Z, Minasov G, Goldstone J, Kelly S, et al.
Res Sq
. 2024 Dec;
PMID: 39711526
Cytochromes P450 (CYP) form one of the largest enzyme superfamilies on Earth, with similar structural fold but biological functions varying from synthesis of physiologically essential compounds to metabolism of myriad...
4.
Lamb D, Goldstone J, Belhaouari D, Andreani J, Farooqi A, Allen M, et al.
Res Sq
. 2024 Nov;
PMID: 39502774
Cytochrome b5 is a small electron transport protein that is found in animals, plants, fungi and photosynthetic proteobacteria where it plays key metabolic roles in energy production, lipid and sterol...
5.
Evensen K, Rusin E, Robinson W, Price C, Kelly S, Lamb D, et al.
Sci Rep
. 2024 Oct;
14(1):23890.
PMID: 39396059
Mollusks are the second most diverse animal phylum, yet little is known about their endocrinology or how they respond to endocrine disrupting compound (EDC) pollution. Characteristic effects of endocrine disruption...
6.
OConnor-Moneley J, Fletcher J, Bean C, Parker J, Kelly S, Moran G, et al.
PLoS One
. 2024 Aug;
19(8):e0308665.
PMID: 39121069
Development of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species. The uniquely expanded C. albicans TLO gene family...
7.
Xie J, Rybak J, Martin-Vicente A, Guruceaga X, Thorn H, Nywening A, et al.
Nat Commun
. 2024 May;
15(1):4261.
PMID: 38769341
Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane. Inhibition of a separate ergosterol biosynthetic step, catalyzed...
8.
Rybak J, Xie J, Martin-Vicente A, Guruceaga X, Thorn H, Nywening A, et al.
Nat Commun
. 2024 Apr;
15(1):3642.
PMID: 38684680
Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific...
9.
Hargrove T, Lamb D, Wawrzak Z, Hull M, Kelly S, Guengerich F, et al.
J Med Chem
. 2024 Apr;
67(9):7443-7457.
PMID: 38683753
are free-living pathogenic protozoa that cause blinding keratitis, disseminated infection, and granulomatous amebic encephalitis, which is generally fatal. The development of efficient and safe drugs is a critical unmet need....
10.
Song Y, Amaya J, Murarka V, Mendez H, Hogan M, Muldoon J, et al.
Org Biomol Chem
. 2024 Mar;
22(14):2835-2843.
PMID: 38511621
Activation of a silent gene cluster in leads to synthesis of a cinnamoyl-containing non-ribosomal peptide (CCNP) that is related to skyllamycins. This novel CCNP was isolated and its structure was...