The Journal of Clinical Investigation
Overview
The Journal of Clinical Investigation is a prestigious peer-reviewed medical journal that publishes cutting-edge research in the field of clinical medicine and biomedical sciences. It provides a platform for scientists, clinicians, and researchers to share their discoveries and advancements in understanding disease mechanisms, diagnostics, therapeutics, and patient care. With a focus on translational research, this journal plays a vital role in bridging the gap between laboratory findings and clinical applications, ultimately improving patient outcomes and advancing medical knowledge.
Details
Details
Abbr.
J Clin Invest
Start
1924
End
Continuing
Frequency
Twenty-four issues a year, 2021-
p-ISSN
0021-9738
e-ISSN
1558-8238
Country
United States
Language
English
Specialty
General Medicine
Metrics
Metrics
h-index / Ranks: 22
544
SJR / Ranks: 278
4833
CiteScore / Ranks: 235
23.70
JIF / Ranks: 208
15.9
Recent Articles
1.
Gauthier T, Lim Y, Jin W, Liu N, Patino L, Chen W, et al.
J Clin Invest
. 2025 Mar;
PMID: 40067393
Phosphorylation of Smad3 is a critical mediator of TGF-β signaling, which plays an important role in regulating innate immune responses. However, whether Smad3 activation can be regulated in innate immune...
2.
He D, Ma J, Zhou Z, Qi Y, Lian Y, Wang F, et al.
J Clin Invest
. 2025 Mar;
PMID: 40067382
Osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) has been recognized as the principal mechanism underlying vascular calcification (VC). Runt-related transcription factor 2 (RUNX2) in VSMCs plays a pivotal role...
3.
Hyun H, Sun B, Yazdimamaghani M, Wielgus A, Wang Y, Montgomery S, et al.
J Clin Invest
. 2025 Mar;
PMID: 40067370
Biological targeting is crucial for effective cancer treatment with reduced toxicity but is limited by the availability of tumor surface markers. To overcome this, we developed a nanoparticle-based, Tumor-specific suRfACE...
4.
Peltier S, Marin M, Dzieciatkowska M, Dussiot M, Roy M, Bruce J, et al.
J Clin Invest
. 2025 Mar;
PMID: 40067362
Although refrigerated storage slows the metabolism of volunteer donor RBCs, which is essential in transfusion medicine, cellular aging still occurs throughout this in vitro process. Storage-induced microerythrocytes (SMEs) are morphologically-altered...
5.
Wei J, Moon J, Yasumizu Y, Zhang L, Raddassi K, Buitrago-Pocasangre N, et al.
J Clin Invest
. 2025 Mar;
PMID: 40067358
Multiple sclerosis (MS) is a complex genetically mediated autoimmune disease of the central nervous system where anti-CD20-mediated B cell depletion is remarkably effective in the treatment of early disease. While...
6.
Farokhnia M, Tazare J, Pince C, Bruns Vi N, Gray J, Lo Re Iii V, et al.
J Clin Invest
. 2025 Mar;
PMID: 40048376
Background: Despite growing preclinical evidence that glucagon-like peptide-1 receptor agonists (GLP-1RAs) could be repurposed to treat alcohol use disorder (AUD), clinical evidence is scarce. Additionally, the potential impact of dipeptidyl...
7.
Naz F, Uddin M, Hagspiel N, Young M, Tyus D, Boone R, et al.
J Clin Invest
. 2025 Mar;
PMID: 40048372
Clostridioides difficile infection (CDI) recurs in one of five patients. Monoclonal antibodies targeting the virulence factor TcdB reduce disease recurrence, suggesting that an inadequate anti-TcdB response to CDI leads to...
8.
Komaru Y, Ning L, Lama C, Suresh A, Kefaloyianni E, Miller M, et al.
J Clin Invest
. 2025 Mar;
PMID: 40048367
Sterile acute kidney injury (AKI) is common in the clinic and frequently associated with unexplained hypoxemia that does not improve with dialysis. AKI induces remote lung inflammation with neutrophil recruitment...
9.
Katusiime M, Neer V, Guo S, Patro S, Wang W, Luke B, et al.
J Clin Invest
. 2025 Mar;
PMID: 40048262
Background: Naïve cells comprise 90% of the CD4+ T-cell population in neonates and exhibit distinct age-specific capacities for proliferation and activation. We hypothesized that HIV-infected naïve CD4+ T-cell populations in...
10.
Keefe J, Aguilar-Sanchez Y, Navarro-Garcia J, Ong I, Li L, Paasche A, et al.
J Clin Invest
. 2025 Mar;
PMID: 40048254
Postoperative atrial fibrillation (poAF) is AF occurring days after surgery with a prevalence of 33% among patients undergoing open-heart surgery. The degree of postoperative inflammation correlates with poAF risk, but...