Tom Huxford
Overview
Explore the profile of Tom Huxford including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
998
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Recent Articles
1.
Suryajaya W, Biswas T, Shahabi S, Mealka M, Huxford T, Ghosh G
Biochemistry
. 2024 Aug;
63(18):2323-2334.
PMID: 39185716
The IκB Kinase (IKK) complex, containing catalytic IKK2 and noncatalytic NEMO subunits, plays essential roles in the induction of transcription factors of the NF-κB family. Catalytic activation of IKK2 via...
2.
Zhu N, Rogers W, Heidary D, Huxford T
Genes Dev
. 2024 Jul;
38(11-12):528-535.
PMID: 38960718
As part of the efforts to understand nuclear IκB function in NF-κB-dependent gene expression, we report an X-ray crystal structure of the IκBζ ankyrin repeat domain in complex with the...
3.
Mealka M, Sierra N, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, et al.
Nat Commun
. 2024 May;
15(1):3785.
PMID: 38710674
Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is...
4.
Neal C, Kronert W, Camillo J, Suggs J, Huxford T, Bernstein S
Aging Cell
. 2024 Mar;
23(6):e14134.
PMID: 38506610
The molecular motor myosin is post-translationally modified in its globular head, its S2 hinge, and its thick filament domain during human skeletal muscle aging. To determine the importance of such...
5.
Mealka M, Sierra N, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, et al.
Res Sq
. 2024 Mar;
PMID: 38464189
Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is...
6.
Mealka M, Sierra N, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, et al.
bioRxiv
. 2024 Jan;
PMID: 38260668
Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is...
7.
Zhu N, Mealka M, Mitchel S, Milani C, Acuna L, Rogers E, et al.
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759710
Though originally characterized as an inactive or transcriptionally repressive factor, the NF-κB p50 homodimer has become appreciated as a physiologically relevant driver of specific target gene expression. By virtue of...
8.
Borar P, Biswas T, Chaudhuri A, Rao T P, Raychaudhuri S, Huxford T, et al.
bioRxiv
. 2023 Sep;
PMID: 37732175
Rapid and high-fidelity phosphorylation of two serines (S32 and S36) of IκBα by a prototype Ser/Thr kinase IKK2 is critical for fruitful canonical NF-κB activation. Here, we report that IKK2...
9.
Holmberg R, Robinson M, Gilbert S, Lujano-Olazaba O, A Waters J, Kogan E, et al.
Mol Cancer Res
. 2022 Oct;
21(2):170-186.
PMID: 36214671
Implications: This study identifies a unique mechanism for the induction of ovarian cancer stem cells that may serve as a novel therapeutic target for preventing relapse.
10.
Rana S, Kour S, Kizhake S, King H, Mallareddy J, Case A, et al.
Bioorg Med Chem Lett
. 2022 Apr;
65:128713.
PMID: 35367592
The IKK-NFκB complex is a key signaling node that facilitates activation of gene expression in response to extracellular signals. The kinase IKKβ and the transcription factor RELA have been targeted...