Tom Huxford
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Explore the profile of Tom Huxford including associated specialties, affiliations and a list of published articles.
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42
Citations
998
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Recent Articles
11.
Ko M, Cohen S, Polley S, Mahata S, Biswas T, Huxford T, et al.
J Biol Chem
. 2022 Mar;
298(5):101864.
PMID: 35339487
Canonical NF-κB signaling through the inhibitor of κB kinase (IKK) complex requires induction of IKK2/IKKβ subunit catalytic activity via specific phosphorylation within its activation loop. This process is known to...
12.
Kour S, Rana S, Kizhake S, Lagundzin D, Klinkebiel D, Mallareddy J, et al.
RSC Chem Biol
. 2022 Feb;
3(1):32-36.
PMID: 35128406
Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-κB subunit RELA has been implicated in several pathological conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that...
13.
Napoleon J, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, et al.
Chem Commun (Camb)
. 2021 May;
57(38):4678-4681.
PMID: 33977973
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a key regulator of the cannonical NF-κB pathway. IKKβ has been validated as a drug target for pathological conditions, which...
14.
Ko M, Biswas T, Mulero M, Bobkov A, Ghosh G, Huxford T
Biochim Biophys Acta Proteins Proteom
. 2020 Aug;
1868(12):140526.
PMID: 32853772
The human IκB Kinase (IKK) is a multisubunit protein complex of two kinases and one scaffolding subunit that controls induction of transcription factor NF-κB activity. IKK behaves as an entity...
15.
Farokhi E, Fleming J, Erasmus M, Ward A, Wu Y, Gutierrez M, et al.
Antibodies (Basel)
. 2020 Apr;
9(2).
PMID: 32316193
LT1009 is a humanized version of murine LT1002 IgG1 that employs two bridging Ca ions to bind its antigen, the biologically active lipid sphingosine-1-phosphate (S1P). We crystallized and determined the...
16.
Caldwell J, Mermelstein D, Walker R, Bernstein S, Huxford T
J Mol Biol
. 2019 Dec;
432(2):427-447.
PMID: 31786266
Drosophila melanogaster is a powerful system for characterizing alternative myosin isoforms and modeling muscle diseases, but high-resolution structures of fruit fly contractile proteins have not been determined. Here we report...
17.
Mulero M, Huxford T, Ghosh G
Adv Exp Med Biol
. 2019 Oct;
1172:207-226.
PMID: 31628658
The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the regulation of numerous biological processes including development of the immune system, inflammation, and innate and adaptive immune...
18.
Mulero M, Wang V, Huxford T, Ghosh G
Nucleic Acids Res
. 2019 Sep;
47(19):9967-9989.
PMID: 31501881
The NF-κB family of dimeric transcription factors regulates transcription by selectively binding to DNA response elements present within promoters or enhancers of target genes. The DNA response elements, collectively known...
19.
Maniaci B, Lipper C, Anipindi D, Erlandsen H, Cole J, Stec B, et al.
Biochemistry
. 2019 Apr;
58(17):2199-2207.
PMID: 30938154
The ability to precisely control protein complex formation has high utility in the expanding field of biomaterials. Driving protein-protein binding through metal-ligand bridging interactions is a promising method of achieving...
20.
Mulero M, Shahabi S, Ko M, Schiffer J, Huang D, Wang V, et al.
Biochemistry
. 2018 May;
57(20):2943-2957.
PMID: 29708732
Transcription activator proteins typically contain two functional domains: a DNA binding domain (DBD) that binds to DNA with sequence specificity and an activation domain (AD) whose established function is to...