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Research Square

Research Square is a scientific journal, published since 2019 in English. The journal's country of origin is United States.
Details
Abbr. Res Sq
Start 2019
End Continuing
Frequency Continuously updated
e-ISSN 2693-5015
Country United States
Language English
Recent Articles
1.
Supercooled storage of red blood cells slows down the metabolic storage lesion
Nemkov T, Isiksacan Z, William N, Senturk R, Boudreau L, Yarmush M, et al.
Res Sq . 2025 Mar; PMID: 40060052
Red blood cell (RBC) transfusion, a life-saving intervention, is limited by reduced RBC potency over time. Cold storage at + 4°C for up to 42 days can reduce transfusion efficacy...
2.
Neural circuit plasticity transforms infant neglect into maternal care
Bair-Marshall C, Froemke R, Cassel N, Bair-Marshall C, Cassel N, Bkhiet M, et al.
Res Sq . 2025 Mar; PMID: 40060051
Infants in distress evoke strong emotional responses in adults, which help to elicit caretaking behaviors from parents to ensure infant needs are met1-3. However, neonatal care can also be challenging,...
3.
Fast, flexible analysis of differences in cellular composition with crumblr
Hoffman G, Hoffman G, Roussos P
Res Sq . 2025 Mar; PMID: 40060050
Changes in cell type composition play an important role in human health and disease. Recent advances in single-cell technology have enabled the measurement of cell type composition at increasing cell...
4.
Optimal scaling of protein-water interactions coupled with targeted torsional refinements yields balanced force fields suitable for simulations of single-chain folded proteins, disordered polypeptides, and protein-protein complexes
Mittal J, Phan T, Mohanty P
Res Sq . 2025 Mar; PMID: 40060049
All-atom molecular dynamics (MD) simulations based on physics-based force fields, serve as an essential complement to experiments for investigating protein structure, dynamics, and interactions. Despite significant advances in force field...
5.
The Wechsler Intelligence Scale for Children, fourth and fifth editions perform comparably in children with Batten Disease
Adams H, Augustine E, Bonifacio K, Collins A, Vierhile A, Mink J
Res Sq . 2025 Mar; PMID: 40060048
The neuronal ceroid lipofuscinoses (Batten disease) are rare neurodegenerative lysosomal storage diseases principally of childhood onset and an autosomal recessive inheritance pattern. Cognitive regression is a hallmark of the disease,...
6.
Inferring directed spectral information flow between mixed-frequency time series
Xian Q, Chen Z, Chen Z
Res Sq . 2025 Mar; PMID: 40060047
Identifying directed spectral information flow between multivariate time series is important for many applications in finance, climate, geophysics and neuroscience. Spectral Granger causality (SGC) is a prediction-based measure characterizing directed...
7.
Motivating Effects of Negative-hedonic Valence Encoded in Engrams
Nedelescu H, Meamari E, Rajaei N, Grey A, Bullard R, OConnor N, et al.
Res Sq . 2025 Mar; PMID: 40060046
Engrams are neuronal alterations that encode associations between environmental contexts and subjectively rewarding or aversive experiences within sparsely activated neuronal assemblies that regulate behavioral responses. How positive- or negative-hedonic states...
8.
Structural Causes of Pattern Formation and Loss Through Model-Independent Bifurcation Analysis
OBrien L, Dawes A
Res Sq . 2025 Mar; PMID: 40060045
During development, precise cellular patterning is essential for the formation of functional tissues and organs. These patterns arise from conserved signaling networks that regulate communication both within and between cells....
9.
Postpartum women's prospective acceptability of long-acting HIV prevention approaches in Kenya: A qualitative study
Concepcion T, Kinuthia J, Otieno F, Akim E, Aketch H, Gomez L, et al.
Res Sq . 2025 Mar; PMID: 40060044
New long-acting pre-exposure prophylaxis (LA-PrEP) options offer an alternative to daily oral PrEP, which poses difficulties for adherence, especially during pregnancy and postpartum. Yet, limited data exist on LA-PrEP acceptability...
10.
A Stratified Precision Medicine Trial Targeting Selective Mechanisms of Alpha 2A Agonism as a Treatment for the Cognitive Biotype of Depression: The BIomarker Guided (BIG) Study for Depression
Williams L, Hack L, Jubeir J, Hilton R, Tozzi L, Boyar L, et al.
Res Sq . 2025 Mar; PMID: 40060043
Cognitive impairments contribute significantly to psychosocial dysfunction in major depressive disorder (MDD), yet mechanistically selective treatments targeted to these impairments are lacking. We evaluated guanfacine immediate release (GIR), an alpha...