Elizabeth A Komives
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Explore the profile of Elizabeth A Komives including associated specialties, affiliations and a list of published articles.
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151
Citations
3441
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Recent Articles
1.
Parra R, Komives E, Wolynes P, Ferreiro D
ArXiv
. 2025 Feb;
PMID: 39975445
Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads of proteins participate in elaborate networks of interactions and perform chemical activities coordinating the...
2.
Komives E, Chiosis G
Curr Opin Struct Biol
. 2024 Dec;
90:102953.
PMID: 39642844
No abstract available.
3.
Chatterjee A, Gallent B, Katiki M, Qian C, Harter M, Silletti S, et al.
Nat Commun
. 2024 Oct;
15(1):9037.
PMID: 39426953
The CUT and homeodomain are ubiquitous DNA binding elements often tandemly arranged in multiple transcription factor families. However, how the CUT and homeodomain work concertedly to bind DNA remains unknown....
4.
Lin C, Li H, Brogan D, Wang T, Akbari O, Komives E
bioRxiv
. 2024 Aug;
PMID: 39211128
Type III-E CRISPR-Cas effectors, of which Cas7-11 is the first, are single proteins that cleave target RNAs without nonspecific collateral cleavage, opening new possibilities for RNA editing. Biochemical experiments combined...
5.
Lin C, Komives E
Curr Opin Struct Biol
. 2024 Jul;
88:102879.
PMID: 39013361
The cellular process by which the protein ubiquitin (Ub) is covalently attached to a protein substrate involves Ub activating (E1s) and conjugating enzymes (E2s) that work together with a large...
6.
Torres-Paris C, Song H, Engelberger F, Ramirez-Sarmiento C, Komives E
Biochemistry
. 2024 May;
63(11):1434-1444.
PMID: 38780522
The active form of the murine urokinase-type plasminogen activator (muPA) is formed by a 27-residue disordered light chain connecting the amino-terminal fragment (ATF) with the serine protease domain. The two...
7.
Mealka M, Sierra N, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, et al.
Nat Commun
. 2024 May;
15(1):3785.
PMID: 38710674
Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is...
8.
Mealka M, Sierra N, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, et al.
Res Sq
. 2024 Mar;
PMID: 38464189
Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is...
9.
Mealka M, Sierra N, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, et al.
bioRxiv
. 2024 Jan;
PMID: 38260668
Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is...
10.
Komives E
Biochem Soc Trans
. 2023 Dec;
51(6):2085-2092.
PMID: 38095058
The nuclear factor-κB (NF-κB) transcription activation system involves disordered regions of both the NF-κB dimers and their inhibitors, the IκBs. The system is well-studied both at the cellular and biophysical...