Thomas R Ioerger
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Explore the profile of Thomas R Ioerger including associated specialties, affiliations and a list of published articles.
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134
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7694
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Recent Articles
1.
Green S, Harrison J, Thompson S, Murugesan D, Libardo M, Engelhart C, et al.
ACS Infect Dis
. 2025 Feb;
11(3):715-726.
PMID: 40014668
Although not currently in the infectious disease spotlight, there is still a pressing need for new agents to treat tuberculosis caused by . As there is an ever-increasing amount of...
2.
Luna M, Oluoch P, Miao J, Culviner P, Papavinasasundaram K, Jaecklein E, et al.
mBio
. 2025 Jan;
16(3):e0376224.
PMID: 39873486
Importance: (Mtb) is responsible for more deaths worldwide than any other single infectious agent. Understanding how this pathogen adapts to the varied environmental pressures imposed by host immunity and antibiotics...
3.
Akusobi C, Choudhery S, Benghomari B, Wolf I, Singhvi S, Ioerger T, et al.
mBio
. 2025 Jan;
16(2):e0337624.
PMID: 39745363
Importance: This study investigates the genetic diversity of (), a bacteria known for causing difficult-to-treat infections. Researchers performed transposon-sequencing (TnSeq) on 21 different clinical isolates of to identify essential and...
4.
Tobias Cudahy P, Liu P, Warren J, Sobkowiak B, Yang C, Ioerger T, et al.
Emerg Infect Dis
. 2024 Jul;
30(8):1562-1570.
PMID: 39043390
Little is known about environmental transmission of Mycobacterium kansasii. We retrospectively investigated potential environmental acquisition, primarily water sources, of M. kansasii among 216 patients with pulmonary disease from an industrial...
5.
Podlesainski D, Adeniyi E, Groner Y, Schulz F, Krisilia V, Rehberg N, et al.
Cell Chem Biol
. 2024 Jul;
31(10):1755-1771.e73.
PMID: 38981479
Spread of antimicrobial resistances urges a need for new drugs against Mycobacterium tuberculosis (Mtb) with mechanisms differing from current antibiotics. Previously, callyaerins were identified as promising anti-tubercular agents, representing a...
6.
Choudhery S, DeJesus M, Srinivasan A, Rock J, Schnappinger D, Ioerger T
PLoS Comput Biol
. 2024 May;
20(5):e1011408.
PMID: 38768228
An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and...
7.
Choudhery S, Ioerger T
ACM BCB
. 2024 Jan;
2023.
PMID: 38162633
One of the challenges in RNA-Seq studies is finding subsets of genes that share a common mechanism of action or are associated with a regulon/pathway. Existing approaches often extract modules...
8.
Zhou Y, Sun H, Rapiejko A, Vargas-Blanco D, Martini M, Chase M, et al.
J Biol Chem
. 2023 Oct;
299(11):105312.
PMID: 37802316
The mechanisms and regulation of RNA degradation in mycobacteria have been subject to increased interest following the identification of interplay between RNA metabolism and drug resistance. Mycobacteria encode multiple ribonucleases...
9.
Matern W, Harris H, Danchik C, McDonald M, Patel G, Srivastava A, et al.
Microorganisms
. 2023 Sep;
11(9).
PMID: 37764112
(), the causative agent of tuberculosis (TB), poses a global health challenge and is responsible for over a million deaths each year. Current treatment is lengthy and complex, and new,...
10.
Yadav V, Boshoff H, Trifonov L, Roma J, Ioerger T, Barry 3rd C, et al.
ACS Med Chem Lett
. 2023 Sep;
14(9):1275-1283.
PMID: 37736177
The continuing prevalence of drug-resistant tuberculosis threatens global TB control programs, highlighting the need to discover new drug candidates to feed the drug development pipeline. In this study, we describe...