Dirk Schnappinger
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Explore the profile of Dirk Schnappinger including associated specialties, affiliations and a list of published articles.
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114
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6488
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Recent Articles
1.
Green S, Harrison J, Thompson S, Murugesan D, Libardo M, Engelhart C, et al.
ACS Infect Dis
. 2025 Feb;
11(3):715-726.
PMID: 40014668
Although not currently in the infectious disease spotlight, there is still a pressing need for new agents to treat tuberculosis caused by . As there is an ever-increasing amount of...
2.
Liu Q, Engelhart C, Wallach J, Tiwari D, Ge P, Manna A, et al.
J Med Chem
. 2025 Jan;
68(3):3065-3087.
PMID: 39823202
The antibacterial agent Bio-AMS is metabolized in vivo through hydrolysis of the central acyl-sulfamide linker leading to high clearance and release of a moderately cytotoxic metabolite . Herein, we disclose...
3.
Smith A, Su H, Wallach J, Liu Y, Maiello P, Jacob Borish H, et al.
Nat Microbiol
. 2025 Jan;
10(2):468-481.
PMID: 39794473
Improved vaccination strategies for tuberculosis are needed. Intravenous (i.v.) delivery of live attenuated Mycobacterium bovis BCG provides protection against Mycobacterium tuberculosis (Mtb) in macaques but poses safety challenges. Here we...
4.
Wang X, Su H, Wallach J, Wagner J, Braunecker B, Gardner M, et al.
Nat Microbiol
. 2025 Jan;
10(2):482-494.
PMID: 39794471
Human challenge experiments could accelerate tuberculosis vaccine development. This requires a safe Mycobacterium tuberculosis (Mtb) strain that can both replicate in the host and be reliably cleared. Here we genetically...
5.
Miller A, Marks F, Chan L, Botella H, Schnappinger D, Ehrt S
Microbiol Spectr
. 2024 Jun;
12(7):e0048724.
PMID: 38860795
Iron scavenging is required for full virulence of mycobacterial pathogens. During infection, the host immune response restricts mycobacterial access to iron, which is essential for bacterial respiration and DNA synthesis....
6.
Choudhery S, DeJesus M, Srinivasan A, Rock J, Schnappinger D, Ioerger T
PLoS Comput Biol
. 2024 May;
20(5):e1011408.
PMID: 38768228
An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and...
7.
Qu D, Ge P, Botella L, Park S, Lee H, Thornton N, et al.
Nat Commun
. 2024 May;
15(1):4161.
PMID: 38755122
Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for posttranslational modification of key enzymes. However, the mycobacterial biotin synthetic pathway is not fully understood. Here, we show that...
8.
Grigsby S, Prasad G, Wallach J, Mittal E, Hsu F, Schnappinger D, et al.
Cell Rep
. 2024 May;
43(5):114201.
PMID: 38728136
No abstract available.
9.
Bosch B, DeJesus M, Schnappinger D, Rock J
Ann N Y Acad Sci
. 2024 Apr;
1535(1):10-19.
PMID: 38595325
Mycobacterium tuberculosis remains the most common infectious killer worldwide despite decades of antitubercular drug development. Effectively controlling the tuberculosis (TB) pandemic will require innovation in drug discovery. In this review,...
10.
Krieger I, Yalamanchili S, Dickson P, Engelhart C, Zimmerman M, Wood J, et al.
ACS Infect Dis
. 2024 Apr;
10(5):1561-1575.
PMID: 38577994
DNA-encoded chemical library (DEL) technology provides a time- and cost-efficient method to simultaneously screen billions of compounds for their affinity to a protein target of interest. Here we report its...