Michael A DeJesus
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Explore the profile of Michael A DeJesus including associated specialties, affiliations and a list of published articles.
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23
Citations
1516
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Recent Articles
1.
Mishra S, Singh P, Hu X, Lopez-Quezada L, Jinich A, Jahn R, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2425981122.
PMID: 40053362
(Mtb), a leading cause of death from infection, completes its life cycle entirely in humans except for transmission through the air. To begin to understand how Mtb survives aerosolization, we...
2.
Choudhery S, DeJesus M, Srinivasan A, Rock J, Schnappinger D, Ioerger T
PLoS Comput Biol
. 2024 May;
20(5):e1011408.
PMID: 38768228
An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and...
3.
Bosch B, DeJesus M, Schnappinger D, Rock J
Ann N Y Acad Sci
. 2024 Apr;
1535(1):10-19.
PMID: 38595325
Mycobacterium tuberculosis remains the most common infectious killer worldwide despite decades of antitubercular drug development. Effectively controlling the tuberculosis (TB) pandemic will require innovation in drug discovery. In this review,...
4.
Eckartt K, Delbeau M, Munsamy-Govender V, DeJesus M, Azadian Z, Reddy A, et al.
Nature
. 2024 Mar;
628(8006):186-194.
PMID: 38509362
Drug-resistant bacteria are emerging as a global threat, despite frequently being less fit than their drug-susceptible ancestors. Here we sought to define the mechanisms that drive or buffer the fitness...
5.
Poulton N, DeJesus M, Munsamy-Govender V, Kanai M, Roberts C, Azadian Z, et al.
Cell Chem Biol
. 2024 Jan;
31(4):669-682.e7.
PMID: 38266648
Pathogenic mycobacteria are a significant cause of morbidity and mortality worldwide. The conserved whiB7 stress response reduces the effectiveness of antibiotic therapy by activating several intrinsic antibiotic resistance mechanisms. Despite...
6.
Choudhery S, DeJesus M, Srinivasan A, Rock J, Schnappinger D, Ioerger T
bioRxiv
. 2023 Aug;
PMID: 37577548
An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and...
7.
Poulton N, DeJesus M, Munsamy-Govender V, Roberts C, Azadian Z, Bosch B, et al.
bioRxiv
. 2023 Jun;
PMID: 37333137
Pathogenic mycobacteria are a significant cause of morbidity and mortality worldwide. These bacteria are highly intrinsically drug resistant, making infections challenging to treat. The conserved stress response is a key...
8.
Poulton N, Azadian Z, DeJesus M, Rock J
Antimicrob Agents Chemother
. 2022 Aug;
66(9):e0090422.
PMID: 35920665
Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5 million deaths worldwide each year. Due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb)...
9.
Li S, Poulton N, Chang J, Azadian Z, DeJesus M, Ruecker N, et al.
Nat Microbiol
. 2022 May;
7(6):766-779.
PMID: 35637331
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance to all antituberculars...
10.
Babunovic G, DeJesus M, Bosch B, Chase M, Barbier T, Dickey A, et al.
mBio
. 2022 Jan;
13(1):e0368321.
PMID: 35038923
Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can kill the infecting bacterium when appropriately activated. To identify mechanisms of clearance, we compared levels of bacterial restriction...